| Method for Optically Monitoring Anthrax Infection Events in Real Time Using Luciferase Tagged Bacteria and in Vivo Imaging Techniques |
DEC 2004 |
3 pages |
| Authors:
Rina Das; Maria Mayda; Sachin Mani; Marti Jett; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
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 | The recent exposures to Bacillus anthracis have highlighted certain issues that are unclear, especially the time frame for which spores could reside in the lungs, the dose, and their potential to subsequently cause a lethal outcome. It is important to find a technique that will allow for visual monitoring of the entire infection process of anthrax in real time to get a better understanding of the sequence of events and ... |
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| Global Gene Expression Analysis to Unambiguously Identify Host Gene Responses Characteristic of Exposure to Biothreat Agents |
DEC 2004 |
9 pages |
| Authors:
Rasha Hammamieh; Marti Jett; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DEPT OF MOLECULAR PATHOLOGY
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| We are studying the complex interaction between various biological pathogens and the host to understand the basis infectious or biothreat-induced diseases and to identify host defense strategies and the mechanisms by which they are regulated. Although gene response profiles show unique signatures quite rapidly after exposure, they also have the potential to reveal phases of progression of illness to a) provide stage-specific diagnosis and b) identification of potential molecular targets ... |
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| Host Gene Expression Responses to Biothreat and Infectious Agents: Implications for Mathematical Modeling of in vitro Responses |
JUN 2004 |
13 pages |
| Authors:
Rasha Hammamieh; Rina Das; Roger Neill; Chanaka Mendis; Shuguan Bi; Sachin Mani; George Ludwig; Marti Jett; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
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| Detection of exposure to biological threat agents currently uses culture methods, immunoassay and gene amplification and these methods constantly are being perfected for greater sensitivity. However, recent events have demonstrated that assessing exposure to a biological threat agent well in advance of onset of illness or at various stages post-exposure would be an important capability to have among the diagnostic options. There is an urgent need for better diagnostic tools ... |
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| Breast Cancer in African American Women: Molecular Analysis of Differences in Incidence and Outcomes |
OCT 2002 |
139 pages |
| Authors:
Agnes Day; John Stubbs; Rina Dad; Marti Jett; HOWARD UNIV WASHINGTON DC
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| Breast cancer mortality in higher among West African and African American women than it is among caucasian women in the United States, but the reasons for theses difference are not known. To devise effective methods for preventing breast cancer, we must understand which factors alone or in combination raise the risk of triggering a tumor, and which factors protect against the disease. Specific goals for the proposed research are to: ... |
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| The Staphylococcal Enterotoxins |
SEP 2001 |
30 pages |
| Authors:
Marti Jett; Boris Iomin; Rina Das; Roger Neill; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF PATHOLOGY
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| Staphylococcal enterotoxins (SEs) constitute a family of related proteins whose biological toxicities include staphylococcal food poisoning (SFP) , various skin disorders toxic shock syndrome (TSS), and possible involvement in autoimmune disorders. The SEs (named sequentially by letter) include SEA, B, C1, C2, C3, D, E, G, H, I, J and toxic shock syndrome toxin (TSST-1); their properties will be compared in throughout this discussion . They have been thoroughly characterized ... |
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| Identification of Changes in Gene Expression Induced by Toxic Agents: Implications for Therapy and Rapid Diagnosis |
2001 |
11 pages |
| Authors:
Marti Jett; Rina Das; Christanio Cummings; Chanaka Mendis; Roger Neill; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DEPT OF MOLECULAR PATHOLOGY
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| In our changing world, there has been a significant increase in both the nature and degree of the threat posed by the use of biological agents. Studies for many years have focused on rapid detection of known biological threat agents using structural-based probes designed and directed toward features of the pathogenic agent. However, concerns relating to unidentifiable pathogens, that could result from either deliberate or natural mutation processes have prompted ... |
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| Fatty Acid Binding Proteins in Prostate Cancer |
JAN 2000 |
43 pages |
| Authors:
Marti Jett; Fred Hawkins; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| We have shown that there is a distinct pattern of fatty acid binding protein (FAEP) expression in prostate cancer vs normal cells and that finding has be confirmed in patient samples of biopsy specimens. Of 6 different FABP studied, certain WABP were identified as markers that may be exploited to reveal stage or aggressiveness of prostate cancer. Since FAEP are secreted from cells, we have shown ... |
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| Arachidonate Metabolism in Breast Cancer Cultures: Identification of Antagonists/Agonists for Possible Intervention Strategies |
OCT 1998 |
127 pages |
| Authors:
Marti Jett; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| There has been increasing evidence that high intake of dietary fats and obesity, in general, correlate with increased risk 0 breast cancer. The breast, as an apocrine gland shrouded in fat pads, may possess special regulatory mechanisms to protect the epithelial cells from stimulation in the rich mileu of the surroundings. Our hypothesis suggests that loss of protective mechanisms in breast tissue leaves breast epithelial cells vulnerable to unregulated stimulation. ... |
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| Arachidonate Metabolism in Breast Cancer Cultures: Identification of Antagonist/Agonist for Possible Intervention Strategies |
OCT 1997 |
124 pages |
| Authors:
Marti Jett; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| There has been increasing evidence that high intake of dietary fats and obesity, in general, correlate with increased risk of breast cancer. The breast, as an apocrine gland shrouded in fat pads, may Possess special regulatory mechanisms to protect the epithelial cells from stimulation by products generated in the rich mileu of the surroundings. Our hypothesis addresses that issue suggesting that loss of protective regulatory mechanisms in breast tissue leaves ... |
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| Arachidonate Metabolism in Breast Cancer Cultures |
OCT 1996 |
45 pages |
| Authors:
Marti Jett; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| This study was initiated based on the the fact that there has been little understanding of the role of bioactive lipids in breast cancer, an epocrine gland whose function involves lipid generation. Many of the arachidonate metabolites have been characterized as initiating cascades of other biologically active molecules such as cytokines, activation of kinases and calcium mobilization; these activators of cellular signals have even been shown to alter nuclear receptors ... |
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| Arachidonate Metabolism in Breast Cancer Cultures: Identification of Antagonists/Agonist for Possible Intervention Strategies |
01 OCT 1995 |
28 pages |
| Authors:
Marti Jett; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| MCF-7 wild type (WT) cells have been examined for their sensitivity to various inhibitors of arachidonate metabolism as outlined in the proposal. One aim was to determine the effects of cyclooxygenase(CO) vs lipoxygenase(LO) inhibitors on proliferation in breast cancer cultures. Optimal suppression of proliferation was observed using inhibitors of 5-LO, platelet activating factor, and protein kinase C. CO inhibitors stimulated proliferation at conc. specific for PGH synthase-1. New drugs, heteropoly ... |
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