This report is the result of an opportunity. The opportunity brought together consumer need with a promising technical advance. The U.S. Army Institute of Dental Research (USAIDR) formulated the need for a wound dressing able to inhibit the development of infections when medical attention might not be immediately at hand. The technical advance was POROPLASTIC membrane, a porous plastic developed by Moleculon, Inc., which promised to allow the controlled release ...
Gentamicin-loaded Poroplastic membrane wound dressing of defined composition have been furnished to USAIDR, for in vivo evaluation. They have been shown to be effective for control of wound infections in vivo and their sustained release properties were found to contribute significantly to their in vivo effectiveness. Poroplastic preparations loaded with gentamicin and clindamycin have been developed, and their drug delivery properties studied in vitro. Certain of these preparations have been ...
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