| Interferon Alfacon1 is an Inhibitor of SARS-Corona Virus in Cell-Based Models, Antiviral Research |
04 JAN 2005 |
5 pages |
| Authors:
Jason Paragas; Lawrence M. Blatt; Chris Hartmann; John W. Huggins; Tim P. Endy; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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 | Preliminary data examining interferon alfacon1 treatment of SARS-CoV (severe acute respiratory syndrome - corona virus)-infected patients suggests this therapy is well tolerated and of therapeutic benefit. We report herein that interferon alfacon1, has potent in vitro antiviral activity against SARS-CoV. In a cytopathic effect (CPE) assay, interferon alfacon1 inhibited the generation of CPE in a dose-dependent manner with an IC50 of 0,001 g/ml, a clinically achievable level. Furthermore, interferon alfacon1 ... |
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| Interferon Alfacon1 is a Potent Inhibitor of SARS-Corona Virus in Cell- Based Models |
04 JAN 2005 |
5 pages |
| Authors:
Jason Paragas; Lawrence M. Blatt; Chris Hartmann; John W. Huggins; Tim P. Endy; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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| Preliminary data examining interferon alphacon1 treatment of SARS-CoV (severe acute respiratory syndrome-corona virus)-infected patients suggest this therapy is well tolerated and of therapeutic benefit. We report herein that interferon alfacon1, has potent in vitro antiviral activity against SARS-CoV. In a cytopathic effect protection (CPE) assay, interferon alfacon1 inhibited the generation of CPE in a dose-dependent manner with an IC50 of 0.001 g/ml, a clinically achievable level. Furthermore, interferon alphacon1 also ... |
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| Interferon-Beta 1a and SARS Coronavirus Replication |
FEB 2004 |
4 pages |
| Authors:
Lisa E . Hensley; Elizabeth A. Fritz; Peter B. Jahrling; Christopher L. Karp; John W. Huggins; CHILDREN'S HOSPITAL CINCINNATI OH
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| A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus ... |
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| International Symposium on Epidemic Hemorrhagic Fever (Hemorrhagic Fever with Renal Syndrome) Held in Wuhan, Hubei, China on 31 October - 2 November 1988 |
01 OCT 89 |
176 pages |
| Authors:
Hsiang Chin-Min; Zheng Zhi-Ming; John W. Huggins; HUBEI MEDICAL COLL (CHINA) VIRUS RESEARCH INST
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| To hold an International Symposium in HFRS was initially proposed by Dr. Chin-min Hsiang, Professor of Virology of Hubei Medical University and immediately supported by Dr. Jia-qi Yang, president of Hubei Medical University and Dr. David L. Huxsoll, Director of U.S. Army Medical Research Institute of infectious Diseases in 1985, the beginning year of a three-year contract between Hubei medical University and the USAMRIID on a collaboration program of HFRS ... |
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| Ribavirin Prophylaxis and Therapy for Experimental Argentine Hemorrhagic Fever |
SEP 88 |
6 pages |
| Authors:
Kelly T. McKee Jr.; John W. Huggins; Creighton J. Trahan; Bill G. Mahlandt; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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| Junin virus-infected rhesus macaques received prophylactic and therapeutic ribavirin to assess the potential of this drug for treating humans with Argentine hemorrhagic fever. When ribavirin was administered intramuscularly at the time of experimental infection with the lethal P3790 strain of Junin virus, all animals were protected from clinical disease. A delay in the initiation of therapy until after the onset of illness resulted in improvement and resolution of systemic signs ... |
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| Inhibition of RNA Viruses In Vitro and in Rift Valley Fever-Infected Mice by Didemnins A and B, |
29 APR 1982 |
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| Authors:
Peter G. Canonico; Wallace L. Pannier; John W. Huggins; Kenneth L. Rienehart; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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| Hantaan Virus, Aetiological Agent of Korean Haemorrhagic Fever, Has Bunyaviridae-Like Morphology |
1982 |
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| Authors:
John D. White; Frances G. Shirley; George R. French; John W. Huggins; Ho Wang Lee; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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Reports by Author
