We developed a miniswine model of passive heatstroke, in part, to explain the variable hyper-, normo- and hypokalemia seen in heatstroke victims. After a baseline period (Tamb=26-270C), anesthetized and instrumented miniswine (n=13, mass=44.6 kg) were ramped t9 41-430C, 60% RH; 13 controls were treated identically, but Tre was maintained at 3800. Tre of the experimental miniswine rose nearly linearly to 454600 until death (approx. 4h). The response patterns of mean ...
Adult, male rats (300-325 g) were treated with pyridostigmine bromide (n=22) or saline (n=22) to quantitate the effects of severe (64%) cholinesterase inhibition on the ability to work (9.14 m/min, level treadmill) in the heat (35 deg C). Pyridostigmine-treated rats had a mean endurance of 23 min while saline- treated animals ran for nearly 35 min (p
To determine the effects of low-dosage organophosphate administration on exercise in a hot environment, malathion (7.5 mg/day, 4 days) was administered IP to rats, and effected a 35% (p<.01) reduction in plasma cholinesterase levels. Treadmill endurance (9.14m/min, no incline, 35 C ambient) was unaffected when the animals were exercised to hyperthermic exhaustion (Tre about 43 C). While rates of heat gain were similar between groups, malathion- treated rats displayed higher ...
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