Ventilatory acclimatization to high altitude results in alveolar hyperventilation, which is an increase in alveolar ventilation per unit of carbon dioxide production and is associated with a fall in the PC02. A measurement frequently made during acclimatization to high altitude is the total volume of air expired per minute, the minute ventilation. However, the relation of total to alveolar ventilation and the influence of C02 production on the latter at ...
Acute hypoxia stimulates an increase in ventilation but the resulting hypocapnia limits the magnitude of the increase. Thus, the hypoxic ventilatory response is usually measured during isocapnia, but this may not reflect events at high altitude. Possibly the degree of inhibition by hypocapnia might depend on individual ventilatory response to C02 and thus vary between persons. if so, it might be useful to compare between individuals an isocapnic hypoxic ventilatory ...
Hypoxia at high altitude stimulates ventilation but inhibitory influences limit the ventilatory response. Possible inhibitory influences include hypocapnia and depression of ventilation during sustained hypoxia. Our approach was to compare hypoxia ventilatory responses at low altitude with ventilation at high altitude. In 12 subjects we compared responses at acute (< 10 min) isocapnic hypoxia, acute poikilocapnic (no CO2 added) hypoxia and sustained (30 min) hypoxia in Denver, 1600 M, with ...
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