Gary L. Horton - Storming Media

Spontaneous Reactivation of Acetylcholinesterase following Organophosphate Inhibition. III Studies with para-nitrophenyl Methylphenylphosphinate.

DEC 1976

Authors: Claire N. Lieske; James H. Clark; John R. Lowe; Gary L. Horton; Donald K. Jewell; EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

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Inhibition constants for the phosphinylation of eel acetylcholinesterase by para-nitrophenyl methylphenyl-phosphinate are reported, as are the constants for the subsequent spontaneous reactivation reaction. The data support the rationale that phosphinates are ideally suited for studies directed at advantageously perturbing the spontaneous reactivation process. (Author)