Three independent sets of normal breast tissues without evidence of cancer, either obtained from patients undergoing reduction mammoplasty or in women at time of autopsy, have been analyzed. The postdoctoral trainee has shown that moderate to dramatic telomere shortening occurs specifically in luminal epithelial cells, but not in myoepithelial cells, in the majority of histologically normal terminal ductal lobular units. However, the extent and degree of telomere shortening varies by ...
We have shown in two independent retrospective studies that loss of telomere DNA content (TC) has potential value in predicting clinical outcome in breast cancer. However, an alternative marker for TC, which could be assessed in samples with small numbers of cells, such as fine needle aspirates, with commonly used methods is desirable. The aim of this study was to demonstrate that measurement of allelic imbalance (AI), which could be ...
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