The purpose of this research was to develop a gene delivery system that can target breast cancer cells specifically and transfect them efficiently. A biomimetic vector was genetically engineered to contain at precise locations: a) an adenovirus micro peptide to condense pDNA into nanosize particles, b) a synthetic peptide to target breast cancer cells, c) a pH-responsive synthetic fusogenic peptide to disrupt endosome membranes and facilitate escape of the nanoparticles ...
The purpose of this research was to develop a gene delivery system that can target breast cancer cells specifically and transfect them efficiently. Using component integration approach, several subsystems of diverse biological origin were integrated onto a modular platform in order to carry diverse functions of an efficient gene delivery vehicle. A biomimetic vector was genetically engineered to contain at precise locations: a) an adenovirus peptide to condense pDNA into ...
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