| Evaluation of Antileishmanial Drugs in Animal Models |
MAR 2000 |
39 pages |
| Authors:
William L. Hanson; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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 | A total of 34 selected compounds, including natural products, some compounds known to be efficacious against other diseases, cholesterol lowering drugs currently in use in human beings, and pro drugs of the pentamidine type were studied in hamsters at various dosage levels, via various routes and treatment schedules for antileishmanial efficacy against Leishmania (leishmania) donovani. One of the same compounds (Baycol) was studied for efficacy against ... |
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| Evaluation of Potential Antileishmanial Drugs in Animal Models |
APR 97 |
24 pages |
| Authors:
William L. Hanson; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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| A total of 16 selected compounds which included some natural products as well as drugs known to be efficacious against other diseases were studied at various dosage levels and via various routes of administration in hamsters for antileishmanial efficacy against visceral leishmaniasis (Leishmania Leishmania donovani) and three of the same compounds were studied for activity against cutaneous leishmaniasis (Leishmania Vianni panamensis). None of these were efficacious against either leishmania but ... |
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| Testing of Experimental Antileishmanial Compounds |
19 OCT 94 |
15 pages |
| Authors:
William L. Hanson; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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| Six plant derivatives which were selected for in vivo study because of their in vitro antiLeishimanial activity and low toxicity were studied for activity against Leishmania Leishmania donovani and Leishmania Viannia brazitiensis in hamsters. The time interval between completion of treatment and evaluation of results was extended up to 4-6 weeks to evaluate any possible delayed antiLeishmanial activity by the compounds. None of the compounds studied were active in hamsters ... |
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| Study of Compounds for Activity against Leishmania |
27 MAR 94 |
43 pages |
| Authors:
William L. Hanson; Virginia B. Waits; Willie L. Chapman Jr.; J. R. Broderson; GEORGIA UNIV ATHENS DEPT OF PARASITOLOGY
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| During this contract, a total of 205 selected compounds were studied for efficacy against Leishmania Leishmania donovani infections in hamsters. Forty-four of these compounds were active as indicated by 50 percent or greater parasite suppression. Glucantime Indices ranged from 1,418 to 0.351. Among these active compounds were 8-aminoquinolines (which are the most efficacious), phenanthrene methanols, dibenzopyrroles, disulfides, aminothiols, and C- nucleosides. When Glucantime, Pentostam or Amphotericin B were given in ... |
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| Study of Compounds for Activity against Leishmania |
27 OCT 92 |
45 pages |
| Authors:
William L. Hanson; V. B. Waits; W. L. Chapman Jr; GEORGIA UNIV ATHENS DEPT OF PARASITOLOGY
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| During this project period a total of 41 new compounds were studied for antileishmanial activity against Leishmania donovani in hamsters. Only one had measurable suppressive activity and this compound was toxic. one new compound was studied for efficacy against Leishmania braziliensis panamensis and this compound was not active and was toxic when administered via the intramuscular route. A computer search of a total of 736 compounds that have been tested ... |
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| Testing of Experimental Compounds for Efficacy Against Leishmania |
31 OCT 90 |
118 pages |
| Authors:
William L. Hanson; Virginia B. Waits; Willie L. Chapman Jr; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
|
| A total of 1,684 compounds was studied for antileishmanial activity against Leishmania donovani in hamsters. Ninety of these had some suppressive activity, five had activity greater than the reference compound, Glucantime, five had activity approximately equal to that of Glucantime, and the remainder were less active than Glucantime. Several chemical classes including 8- aminoquinolines, purine analogs, quinolines, pyridines, heavy metal complexes, berberine derivatives, and pyrazine or quinazoline inhibitors of dihydrofolate ... |
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| Study of Compounds for Activity against Leishmania |
27 OCT 90 |
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| Authors:
William L. Hanson; V. B. Waits; W. L. Chapman Jr; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
|
 | During the period covered by this report, a total of 75 compounds were tested for efficacy against Leishmania donovani infections in hamsters. A computer analysis of the data from the study of approximately 6000 compounds tested since this project was initiated in 1974 suggested a number of compounds with sufficient promise to warrant further study during this contract period. The 8-aminoquinolines were the most active compounds studied, one of which ... |
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| Testing of Experimental Compounds for Efficacy against Leishmania |
28 FEB 90 |
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| Authors:
William L. Hanson; Virginia B. Waits; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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| Six of a total of 312 compounds of diverse nature which were tested in the primary visceral screening system were noted to have suppressive activity against Leishmania donovani (suppressed parasite numbers in the liver by at least 50% at one of the dosages used). The 8-aminoquinolines were the most active compounds studied with approximately 100% suppression of hepatic parasites at 52 mg/kg dosage. Pyrimidine nucleotides had relatively low efficacy as ... |
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| Testing of Experimental Compounds for Efficacy against Leishmania |
28 FEB 89 |
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| Authors:
William L. Hanson; Virginia B. Waits; Willie L. Chapman Jr; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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| A total of 683 compounds of diverse chemical classes including inosine analogs and analogs of WR06026 were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. A total of 16 of these were active. The 8-aminoquinolines were the most potent of the active compounds but all but one was toxic to the host. The active compounds included some inosine analogs and some analogs ... |
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| Testing of Experimental Compounds for Efficacy against Leishmania |
FEB 88 |
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| Authors:
William L. Hanson; Virginia B. Waits; Willie L. Chapman Jr; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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| A total of 309 new compounds of diverse chemical classes consisting of compounds with activity against other parasites, activity against viruses, or having chemical structures suggestive of being antimetabolites were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Seven of these were active. In comparison to the activity of the reference compound, Glucantime, one-half of these had activity approximately equal to Glucantime ... |
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| Testing of Experimental Compounds for Efficacy against Leishmania |
FEB 87 |
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| Authors:
William L. Hanson; Virginia B. Waits; Willie L. Chapman Jr; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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| A total of 298 compounds were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Twenty-nine of these compounds were noted to have some suppressive activity. The activity of 5 was approximately equal to that of the reference compound, glucantime. Two others (sinefungin and BL11864) had activity considerably greater than that of glucantime (Glucantime Index ranged from 4.04 - 30.2 and 8. 13 ... |
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| Testing of Experimental Compounds for Efficacy Against Leishmania |
01 FEB 86 |
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| Authors:
William L. Hanson; Virginia B. Waits; Willie L. Chapman Jr; GEORGIA UNIV ATHENS
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| A total of 82 compounds were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Thirty-two were noted to have some suppressive activity and 4 of these active compounds had activity greater than that of the reference compound, glucantime (Glucantime Index ranged from 2.62 to 14.18). Sinefungin was included among these highly active compounds. Keywords: Antileishmanial agents, Antileishmanials, Antivirus agents. |
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| Improved Therapy of Leishmaniasis by Encapsulation of Antimonial Drug in Biodegradable Artificial Phospholipid Vesicles (Liposomes), |
JUN 1978 |
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| Authors:
Carl R. Alving; Edgar A. Steck; William L. Hanson; GEORGIA UNIV ATHENS COLL OF VETERINARY MEDICINE
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