Jennifer Gurney - Storming Media

A Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation

23 MAR 2005

13 pages

Authors: Nora Philbin; Jennifer Rice; Jennifer Gurney; Gerald McGwin; Francoise Arnaud; Feng Dong; Todd Johnson; W. S. Flourncy; Stephen Ahlers; L. B. Pearce; Richard McCarron; Daniel Freilich; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

The full text of this report is available for sale.

Objective: To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. Methods: A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and clinical variables were monitored for 4 h (pre-hospital phase) and subsequent fluid ...

A Hemoglobin Based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) versus Hetastarch (HEX) in an Uncontrolled Liver Injury Hemorrhagic Shock Swine Model with Delayed Evacuation

OCT 2004

Authors: Jennifer Gurney; Nora Philbin; Jennifer Rice; Francoise Arnaud; Feng Dong; Meghan Wulster-Radcliffe; Bruce Pearce; Lewis Kaplan; Richard McCarron; Daniel Freilich; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

The full text of this report is not available and therefore is not for sale. This information is provided for reference purposes only.

As HBOC-201 improves outcome in animals with hemorrhagic shock (HS), we compared HBOC-201 and HEX (used by U.S. military special operations forces) in a swine model of delayed evacuation and uncontrolled HS. Twenty-four Yucatan pigs underwent a grade III liver injury and were resuscitated with HBOC-201, HEX, or no fluid (NON). Additional infusions were given for hypotension or tachycardia. After 4 hours, the liver was repaired; IV fluids and blood ...

Bovine Polymerized Hemoglobin (HBOC-201) for the Prehospital Resuscitation of Combat Casualties With Hemorrhagic Shock (HS)

01 SEP 2004

11 pages

Authors: Nora Philbin; Jennifer Rice; Jennifer Gurney; Benjamin Esperat; Noemy Carballo; Felicia Wilson; Francoise Arnaud; Frank Dong; Richard McCarron; Daniel Freilich; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

To compare the physiologic effects of BPH vs. hetastarch (HEX), the current resuscitative fluid used by U.S. Special Forces, in delayed resuscitation HS models simulating battlefield injuries.