We describe the use of quantum-mechanically entangled photons for sensing intrusions across a physical perimeter. Our approach to intrusion detection uses the no-cloning principle of quantum information science as protection against an intruder's ability to spoof a sensor receiver using a 'classical' intercept-resend attack. We explore the bounds on detection using quantum detection and estimation theory, and we experimentally demonstrate the underlying principle of entanglement-based detection using the visibility derived ...