Paul Gordy - Storming Media

DNA Vaccination of the American Crow (Corvus brachyrhynchos) Provides Partial Protection Against Lethal Challenge with West Nile Virus

01 JAN 2007

7 pages

Authors: Michel L. Bunning; Patricia E. Fox; Richard A. Bowen; Nicholas Komar; Gwong-Jen J. Chang; Tully J. Speaker; Michael R. Stephens; Nicole Nemeth; Nicholas A. Panella; Stanley A. Langevin; Paul Gordy; Max Teehee; Patricia R. Bright; Michael J. Turell; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD VIROLOGY DIV

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The New York 1999 strain of West Nile virus (WNV) is nearly 100% fatal in the American crow (Corvus brachyrhynchos). We evaluated four WNV vaccine formulations in American crows, including intramuscular (i.m.) DNA vaccine, i.m. DNA vaccine with adjuvant, orally administered microencapsulated DNA vaccine, and i.m. killed vaccine. Neutralizing antibodies developed in approximately 80% of crows that received the DNA vaccine i.m. (with or without adjuvant), and in 44% that ...