Guinea pigs were exposed 5 days/week/two weeks to saline or one of two sarin doses (0.2 or 0.4 x LD50). Animals were assessed for signs of toxicity, changes in body weight and temperature, EEG activity, behavioral and biochemical parameters during exposure (E1-10) and up to 100 days post-exposure (P100). Red blood cell AChE was depressed 60% and 80% respectively in the 0.2 and 0.4 x LD50 groups following E10, returning ...
This study is assessing the effects in guinea pigs of repeated low-dose exposure to the nerve agent sarin. Preliminary results suggest no effects of either repeated 0.2 or 0.4 X LD50 sarin exposure (compared with saline) on body weight or temperature, general physical signs, flinch threshold or activity level, or on EEG activity. In contrast, RBC cholinesterase levels dropped to 20% of baseline following the tenth exposure in the 0.4 ...
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