To determine antitumor immunity in MMT mice that are deficient for telomerase activity, we immunized MMT, G0 and G1 to G4 mTERC-/-MMT mice with DC/tumor fusion vaccine (FC/MMT). Vaccination of MMT, G0 and G1 to G4 mTERC-/-MMT mice induced CTL that lysed MUC1-positive tumor cells, suggesting that the cellular immunity is not affected by telomerase inactivity, at least in the G1 and G2 mTERC-/-MMT mice. The induction of CTL in ...
The MMT mice develop multiple mammary carcinomas between the ages of 65-108 days with 100% penetrance. The mammary carcinomas occur in multiple stages. In addition, the progressive malignant transformation is closely correlated with telomerase activity using telomeric repeat amplification protocol (TRAP), suggesting that telomerase may be involved in the development of mammary carcinomas. Furthermore, constitutive deletion of the RNA component of telomerase significantly delayed the appearance of tumor and reduced ...
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