| Identification of Pro-Differentiation P53 Target Genes and Evaluation of Expression in Normal and Malignant Mammary Gland |
APR 2006 |
38 pages |
| Authors:
Hua Li; Pratima Cherukuri; Alissa Pho; Victoria Cowling; Michael Cole; Andrew K. Godwin; Wendy Wells; James Direnzo; DARTMOUTH COLL HANOVER NH
|
 | Tumor stem cell theory implies that causative lesions underlying human malignancies occur and are harbored in multi-potent progenitors with retained proliferative capacity and a prolonged lifespan. Transcriptional profiling of human breast cancers has identified five distinct subtypes of which the basal-epithelial subtype is most aggressive, correlates with poor prognosis, and lacks established molecular targets such as ER alpha, PR and Her2- overexpression. These tumors display a high degree of cellular ... |
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| BRCC36, A Novel Subunit of a BRCA1/2 E3 Ubiquitin Ligase Complex: Candidate Breast Cancer Susceptibility Gene |
SEP 2005 |
12 pages |
| Authors:
Andrew K. Godwin; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| liBesides family history of cancer and an individual's age, no single etiologic factor can identify women at an increased risk for the disease. Approximately 10% of all cases of breast cancer exhibit a familial pattern of incidence. Efforts to identify the genetic basis of familial breast cancer reached fruition some years ago, when the breast-cancer susceptibility genes, BRCA1 and BRCA2 were identified. However, recent studies have suggested that mutations in ... |
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| Developing Inhibitors of Ovarian Cancer Progression by Targeted Disruption of the Gamma-Synuclein Activated Migratory and Survival Signaling Pathways |
APR 2005 |
17 pages |
| Authors:
Andrew K. Godwin; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| Synucleins are a family of highly conserved small proteins that are normally expressed predominantly in neurons. Very little is known about the physiological functions of the synucleins. We have reported that g-synuclein (also known as BCSG1) is dramatically up-regulated in the vast majority (>70%) of late-stage breast and ovarian cancers (Bruening, et al., 2000). When over-expressed, g-synuclein significantly stimulates cell proliferation and metastasis in some breast cancer cell lines. We ... |
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| Identification of Two Candidate Tumor Suppressor Genes on Chromosome 17p13.3: Assessment of Their Roles in Breast and Ovarian Carcinogenesis |
JUL 2001 |
98 pages |
| Authors:
Andrew K. Godwin; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| OVCA1 and OVCA2 were first identified by us as candidate tumor suppressor genes, due to the fact that they map to a critical region of frequent allelic loss in breast and ovarian cancer at l7p13.3. Our studies have shown that OVCA1 is mutated in some tumor cell lines, and its protein levels are decreased or lost in nearly 40% of breast and ovarian adenocarcinomas, while OVCA2 appears to be unaffected. ... |
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| Identification of Two Candidate Tumor Suppressor Genes on Chromosome 17p13.3: Assessment of Their Roles in Breast and Ovarian Carcinogenesis |
JUL 1999 |
38 pages |
| Authors:
Andrew K. Godwin; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| Loss of all or part of one copy of chromosome l7p is a frequent event in breast and ovarian tumors. We identified a common region of allelic loss between two highly polymorphic DNA markers on l7pl3.3, YNH37.3 and YNZ22.l. These two markers are separated by less than 20 kbp. To date, only two genes have been reported that map within the critical region, OVCAl and OVCA2. Both OVCAl and OVCA2 ... |
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