| Biodegradable Vaccine Microcapsules for Systemic and Mucosal Immunization against RVF and VEE Viruses |
31 MAR 1992 |
26 pages |
| Authors:
John H. Eldridge; Terrence E. Greenway; Jay K. Staas; Richard M. Gilley; ALABAMA UNIV IN BIRMINGHAM
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 | Immunization with a vaccine against Venesuelan equine encephalitis (VEE) virus encapsulated in microspheres formulated of the biodegradable and biocompatible copolymer poly(DL-loctide-(CO-glycolide) (DL-PLG) was - investigated. Whole 60CO-inactivated and formalin-fixed TC 83 VEE virus was encapsulated in DL-PLG of equal mole parts lactide and glycolide (50:50 DLPLG) by an emulsion-based process to yield microspheres of approximately 1 to 10 micrometers in diameter and containing approximately 0.8% by weight VEE vaccine. As ... |
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| Development of New Immunogens and a Controlled Release Delivery System for Oral Immunization against Staphylococcal Entertoxin B |
17 JAN 90 |
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| Authors:
Jay K. Staas; John H. Eldridge; Richard M. Gilley; Thomas R. Tice; SOUTHERN RESEARCH INST BIRMINGHAM AL
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 | The staphylococcal enterotoxins are extracellular proteins produced by Staphylococcal aureus that have been demonstrated to be a major cause of food poisoning. Serological methods have differentiated five classes of enterotoxins, A, B, C1, C2, D and E. Despite extensive study of the structure and properties of these enterotoxins, their precise mode of action is unclear. While detection of the toxins and prophylaxis of toxemia is of obvious importance to the ... |
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| Enhancement of Antiviral Agents through the Use of Controlled-Release Technology |
17 JAN 90 |
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| Authors:
Michael E. Hudson; Melinda G. Hollingshead; Richard M. Gilley; William M. Shannon; Thomas R. Tice; SOUTHERN RESEARCH INST BIRMINGHAM AL
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| This is our Final Progress Report on Contract DAMD17-86-C-6044, entitled, Enhancement of Antiviral Agents Through the Use of Controlled-Release Technology. It covers research completed during the period from October 15,1985, through July 31,1989. Keywords: Controlled-release, Microcapsules, Drug delivery, Japanese encephalitis, Muramyl tripeptide. (JS) |
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| Enhancement of Antiviral Agents through the Use of Controlled-Release Technology |
11 MAR 88 |
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| Authors:
Thomas R. Tice; Richard M. Gilley; William M. Shannon; Melinda G. Hollingshead; SOUTHERN RESEARCH INST BIRMINGHAM AL
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| The major objectives of this research program are to develop a programmed-release delivery system (microcapsule system) designed to enhance the immunogenic potential of an inactivated (killed) Japanese Encephalitis (JE) virus vaccine, allowing for immunization against this viral agent and, to develop controlled-release microcapsule delivery systems that will enhance the effects of the following immune modulators and antiviral agents: muramyl tripeptide (MTP), interferon (IFN), and poly(riboinosinic acid-ribocytidylic acid) POLY(I C). More ... |
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| Enhancement of Antiviral Agents Through the Use of Controlled-Release Technology |
29 MAY 87 |
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| Authors:
Thomas R. Tice; Richard M. Gilley; K. L. Pledger; William M. Shannon; Melinda G. Hollingshead; SOUTHERN RESEARCH INST BIRMINGHAM AL
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| This First Annual Progress Report covers research completed during the period from November 1, 1985, through January 31, 1987. The major objectives of this research program are a) To develop a programmed-release delivery system (microcapsule system) designed to enhance the immunogenic potential of an inactivated (killed) Japanese Encephalitis (JE) virus vaccine, allowing for immunization against this viral agent and, b) To develop controlled-release microcapsule delivery systems that will enhance the ... |
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| Acute Toxicological Study of Ampicillin Anhydrate Microcapsules in Sprague-Dawley Rats |
01 APR 87 |
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| Authors:
J. D. Prejean; Allan G. Manus; Thomas R. Tice; Richard M. Gilley; Cathy E. Rowe; SOUTHERN RESEARCH INST BIRMINGHAM AL
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| This document contains the results of an acute toxicological study to determine the toxicologic potential of ampicillin anhydrate microcapsules on various organs of the rat. Keywords: Wound treatment; Antibiotic microcapsule; Controlled release; Experimental data; Tables data. (aw) |
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