Hugh A. George - Storming Media

A Recombinant 63-kDa Form of Bacillus anthracis Protective Antigen Produced in the Yeast Saccharomyces cerevisiae Provides Protection in Rabbit and Primate Inhalational Challenge Models of Anthrax Infection

21 OCT 2005

15 pages

Authors: Robert W. Hepler; Rosemarie Kelly; Tessie B. McNeely; Hongxia Fan; Maria C. Losada; Hugh A. George; Andrea Woods; Leslie D. Cope; Alka Bansal; James C. Cook; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

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Infection by Bacillus anthracis is preventable by prophylactic vaccination with several naturally derived and recombinant vaccine preparations. Existing data suggests that protection is mediated by antibodies directed against the protective antigen (PA) component of the anthrax toxin complex. PA is an 83-kDa protein cleaved in vivo to yield a biologically active 63-kDa protein. In an effort to evaluate the potential of yeast as an expression system for the production of ...