| Chlorotrifluoroethylene Oligomer: Evaluation of Acute Delayed Neurotoxicity in Hens, and Study of Absorption and Metabolism in Rats Following Oral, Dermal, and Inhalation Exposure |
SEP 87 |
29 pages |
| Authors:
E. R. Kinkead; C. L. Gaworski; J. R. Horton; T. R. Boosinger; CALIFORNIA UNIV IRVINE
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 | Acute toxicity studies including delayed neurotoxicity, single dose oral, 4- and 6-hour vapor inhalation, and single dose dermal were conducted with the chlorotrifluoroethylene (CTFE) oligomer MLO 83-322. A second sample, MLO 81- 125 from the same lot as MLO 83-322, did not contain the additives and was used only during part of the inhalation study. Hens receiving five consecutive oral doses of up to 9.2 g CTFE/kg body weight remained ... |
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| The Toxicological Evaluation of Polyalphaolefin Hydraulic Fluids |
JUL 87 |
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| Authors:
E. R. Kinkead; C. L. Gaworski; A. P. D'Addario; R. H. Bruner; NORTHROP SERVICES INC-ENVIRONMENTAL SCIENCES DAYTON OH
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 | Acute toxicity studies including eye and skin irritation, skin sensitization, single dose oral, single dose dermal, 4-hour aerosol inhalation were conducted with polyalphaolefin-based hydraulic fluids. In addition, a sample of the polyalphaolefin base fluid was tested in a similar manner. The base fluid, as well as four of the five formulations tested were relatively non- hazardous. One formulation, designated N501, was toxic by aerosol inhalation resulting in 4-hour LC50 values ... |
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| Comparative Studies of the Short-Term Toxicity of the Hydraulic Fluids MIL-H-19457C, MIL-H-19457B, and MIL-H-22072B |
09 JUL 86 |
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| Authors:
C. L. Gaworski; E. R. Kinkead; J. R. Horton; W. J. Bashe; E. L. Einhaus; CALIFORNIA UNIV DAYTON OH
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| Acute toxicity studies including eye and skin irritation, skin sensitization, single dose oral, single dose intraperitoneal, 4-hour aerosol inhalation, single dose dermal, and 21-day repeated aerosol inhalation were conducted with the hydraulic fluids MIL-H-19457C, MIl-H-19457B and MIl-H-22072B. The first two hydraulic fluids are triarylphosphate ester-based materials, while the third is glycol based. MIL-H-19457C and MIl-H-19457B were also tested for neurotoxic potential with a repeated dose screening assay in chickens. None ... |
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| Evaluation of the Acute Toxicity, Irritation, Sensitization, and Subchronic Dermal Toxicity of Antimony Thioantimonate Lubricant |
MAR 86 |
24 pages |
| Authors:
J. R. Horton; C. L. Gaworski; P. E. Newton; R. H. Bruner; CALIFORNIA UNIV DAYTON OH
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| Antimony thioantimonate (ATA) is used in a calcium cup grease (Ca grease) lubricant in Naval operations. Test for acute intraperitoneal toxicity, eye irritation, sensitization and subchronic dermal toxicity were conducted. Single dose IP LD sub 50 values for male and femal Sprague-Dawley rats were 445 mg/kg and 652 mg/kg, respectively. ATA instilled in New Zealand White rabbit eyes produced reversible conjunctival erythema, chemosis and discharge. Superficial corneal injury noted with ... |
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| A One-Year Inhalation Toxicity Study of Otto Fuel II |
DEC 85 |
31 pages |
| Authors:
C. L. Gaworski; H. F. Leahy; W. J. Bashe; J. D. MacEwen; E. H. Vernot; CALIFORNIA UNIV DAYTON OH
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| A 1-year industrial type (6 hours/day, 5 day/week) inhalation exposure was conducted to evaluate the oncogenic potential of the torpedo fuel, Otto Fuel II. Exposure levels of 1.4 mg/cu m and 240 mg/cu m were based on analyzed 1-2 propylene glycol dinitrate (PGDN) concentrations, the major component. Dogs (male and female beagle), rats (male and female Fischer 344), and mice (male and female C57BL/6) were exposed to the lower concentration, ... |
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| Evaluation of 90-Day Inhalation Toxicity of Petroleum and Oil Shale Diesel Fuel Marine (DFM) |
DEC 85 |
38 pages |
| Authors:
C. L. Gaworski; J. D. MacEwen; E. H. Vernot; C. C. Haun; H. F. Leahy; CALIFORNIA UNIV DAYTON OH
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| Subchronic 90 day inhalation toxicity studies were conducted to compare the toxicity of Petroleum and Oil Shale Derived Diesel Fuel Marine (DFM) . Beagle dogs, Fischer 344 rats, and C57BL/6 mice were continuously exposed to DFM at concentrations of 50 mg/cu. m and 300 mg/cu. m. Unexposed controls were also maintained. All dogs and a portion of each rodent group were sacrificed and examined at exposure termination. The remaining rodents ... |
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| Acute Toxicity Studies on Two Air Force Hydraulic Fluids (MLO 82-233 and MLO 82-585) |
NOV 85 |
22 pages |
| Authors:
E. R. Kinkead; J. R. Hotron; C. L. Gaworski; R. A. Salomon; CALIFORNIA UNIV DAYTON OH
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| This report describes results of investigations into the acute toxic properties of two operational Air Force hydraulic fluids, MLO 82-233 and MLO 82- 585. Various routes of administration were investigated including inhalation, dermal, and oral to rats, guinea pigs, rabbits, and chickens. No acute toxicity occurred in rats with either hydraulic fluid as a results of oral or inhalation exposure at the maximum concentration tested. Dermal exposure of rabbits resulted ... |
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| Evaluation of the 90-Day Inhalation Toxicity of Petroleum and Oil Shale JP-5 Jet Fuel |
APR 85 |
40 pages |
| Authors:
C. L. Gaworski; J. D. MacEwen; E. H. Vernot; C. C. Haun; H. F. Leahy; CALIFORNIA UNIV DAYTON OH
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| Subchronic 90-day inhalation studies were conducted to compare the toxicity of Petroleum and Oil Shale derived JP-5 jet fuel. Beagle dogs, Fischer 344 rats, and C57BL/6 mice were continuously exposed to JP-5 at concentrations of 150 mg/m cum and 750 mg/cum 3. Unexposed control groups were also maintained. All dogs and a portion of each rodent group were sacrificed and examined at exposure termination. Remaining rodents were held for observation ... |
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| A 90-Day Vapor Inhalation Toxicity Study of Decalin |
85 |
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| Authors:
C. L. Gaworski; C. C. Haun; J. D. MacEwen; E. H. Vernot; R. H. Bruner; CALIFORNIA UNIV IRVINE TOXIC HAZARDS RESEARCH UNIT
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| A subchronic 90-day inhalation study was conducted to determine the toxic effects of decalin, a commonly used industrial solvent. Experimental groups consisting of male and female beagle dogs, male and female Fischer-344 rats, and female C57BL/6 mice were continuously exposed to decalin concentrations of 5 or 50 ppm. An unexposed control group was also maintained. All dogs and a portion of each rodent group were sacrificed and examined at exposure ... |
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| Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects |
OCT 84 |
52 pages |
| Authors:
C. C. Haun; E. R. Kinkead; E. H. Vernot; C. L. Gaworski; J. D. MacEwen; CALIFORNIA UNIV DAYTON OH
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| Four animal species were exposed for 6-months to selected vapor concentrations of propellant grade unsymmetrical dimethylhydrazine to determine its oncogenic effects. The UDMH concentrations at or near the current threshold limit value were 0.05, 0.5, and 5 ppm. Animals were maintained for various time periods postexposure as long as: hamsters, 17 months; mice and rats, 19 months; and dogs, 54 months. The lung was a target organ in rats while ... |
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| Acute Toxicity of 3,3-Diethynldiphenol Sulfone: An Acetylene Terminated Sulfone |
APR 1982 |
15 pages |
| Authors:
J. R. Horton; C. L. Gaworski; J. D. MacEwen; E. H. Vernot; CALIFORNIA UNIV IRVINE
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| Acetylene terminated sulfone or 3,3-diethynldiphenol sulfone was subjected to a battery of acute animal toxicity studies for estimation of its potential health hazards to production or material handling workers. These studies included acute oral, acute dermal, eye irritation, skin irritation and skin sensitization testing. Inhalation studies could not be performed because the tacky nature of the finely ground material prevented generation of an aerosol. The fine particles rapidly clumped together ... |
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