| Cell-Like Entities: On the Boundary Between Non-Living and Living |
APR 2006 |
29 pages |
| Authors:
John M. Frazier; Nancy Kelley-Loughnane; Mauricio Rodriguez; Leamon Viveros; Sandra Trott; Oleg Paliy; Melanie Tomczak; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH HUMAN EFFECTIVENESS DIRECTORATE
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 | In the last few decades, scientists have learned how to manipulate the basic components of life, how to design biomolecular networks, how to evolve biomolecules with unique characteristics and how to direct and control cellular processes at the molecular level. Using this knowledge as a foundation, it is theoretically possible to conceive of designing biological constructs, which we refer to as cell-like entities (CLEs), that use custom engineered biological machinery ... |
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| Predicting Dose-Response Relationships of Acute Cadmium Hepatoxicity and Metallothionein Regulation in the Rat Via In Vitro to In Vivo Extrapolation |
FEB 2006 |
44 pages |
| Authors:
Jeffery M. Gearhart; Diane M. Todd; John M. Frazier; Ellen L. Ebel; Jeffrey S. Eggers; Teresa R. Sterner; ALION SCIENCE AND TECHNOLOGY CORP DAYTON OH
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| The purpose of this effort was to utilize cadmium, a known toxicant of environmental and occupational concern, to develop an understanding of the relationships between chemical kinetics (rates of chemical movement into the body) and cellular dynamics (cellular response to chemical entering the cells) in order to predict early target organ toxicity and refine/validate a biologically-based kinetic model. This effort involved three studies. The first measured cadmium kinetics over 24 ... |
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| Toxicity of Experimental Jet Fuel System Ice-Inhibiting Agents: I. In Vitro Dosimetry |
OCT 1999 |
33 pages |
| Authors:
Kevin T. Geiss; Dan L. Polland; John M. Frazier; MANTECH GEO-CENTERS JOINT VENTURE DAYTON OH
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| The potential toxicities of compounds to replace current US Air Force operational chemicals is of particular interest. A group of jet fuel system ice-inhibiting agent alternatives currently being evaluated for performance include derivatives of 1,3-dioxolane-4-methanols and 1,3-dioxanes. The experiments presented here were performed in support of Air Force Research Laboratory's Materials Directorate research on FSII alternatives. Our initial approach to evaluating potential toxicity utilized primary rat hepatocyte cultures for assessing ... |
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