Cerissa P. Francisco - Storming Media

The Effects of Repeated Sub-Toxic Sarin Exposure on Behavior, EEG and Blood and Brain AChE Activity

AUG 2005

25 pages

Authors: Melinda R. Roberson; Michelle B. Schmidt; Mary D. Gonzales; Kathleen M. McAvoy; Cerissa P. Francisco; Mark A. Reynolds; John H. McDonough; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

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Guinea pigs were exposed 5 days/week/two weeks to saline or one of two sarin doses (0.2 or 0.4 x LD50). Animals were assessed for signs of toxicity, changes in body weight and temperature, EEG activity, behavioral and biochemical parameters during exposure (E1-10) and up to 100 days post-exposure (P100). Red blood cell AChE was depressed 60% and 80% respectively in the 0.2 and 0.4 x LD50 groups following E10, returning ...