The goal of this project is to evaluate the hypothesis that traumatic brain injury induces alterations in the brain's reward circuitry which may make an injured brain more susceptible to the rewarding effects of opioids. We are currently conducting experiments to evaluate the hypothesis that TBI causes changes in the analgesic response to opioids following acute and repeated drug administration. We are secondly in the midst of testing the hypothesis ...
The purpose of this research is to determine through analytical modeling and animal-based experiments the blast-level threshold for mild traumatic brain injury in humans. We have cataloged brain material properties and determined microtubule geometry and response to mechanical loading. Basic axon geometry has been determined for a finite element (FE) model and modified geometry has also been developed. Blast pressure profiles for small IED and other blast scenarios have been ...
The purpose of this research is to determine through analytical modeling and animal-based experiments the blast-level threshold for mild traumatic brain injury in humans. We have cataloged brain material properties and determined axon bundle geometry. Basic axon geometry has been determined for a finite element (FE) model and modified geometry has also been developed. Blast pressure profiles for small IED and other blast scenarios have been determined from literature reviews. ...
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