The Crk adaptor proteins (CrkI, CrkII and CrkL) play an important role during cellular signalling by mediating the formation of protein complexes. We examined how the loss of Crk would affect tumor progression using RNA interference, as well as examining the consequences of Crk over-expression. For each cancer cell line tested, loss of Crk expression corresponded with a significant decrease in cell migration, invasion, and adhesion, demonstrating that Crk adaptor ...
The Crk adaptor proteins (CrkI, CrkII and CrkL) play an important role during cellular signalling by mediating the formation of protein-protein complexes and are involved in cellular migration, invasion, and adhesion. Targeting CrkI and CrkII in breast cancer cell lines by RNA interference demonstrated that loss of Crk expression corresponded with a significant decrease in cell migration and invasion. This implies that Crk adaptor proteins play an important role in ...
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