When introduced in the 1950s, benzathine penicillin G (BPG) was shown to be effective in eradicating group A beta-hemolytic streptococcus (GAS) for at least 3 weeks after administration. Several studies since the 1990s suggest that at 3-4 weeks serum penicillin G levels are less than adequate (below MIC(exp 90) of 0.016 mg/ml). We studied these levels for 4 weeks after the recommended dose of BPG in military recruits, for whom ...
Group A Streptococcus pyogenes (GAS) exhibits a high degree of clinically relevant phenotypic diversity. Strains vary widely in terms of antibiotic resistance (AbR), clinical severity, and transmission rate. The data show that resistance and virulence are very tightly correlated with the serotype, and that multiple methods of rapidly inferring serotypes are essentially identical in terms of sensitivity and specificity. Recombination, horizontal transfer, and other forms of reassortment are rare in ...
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