The use of 4-dimethylaminopyridine as a catalyst at -78 Degrees c cuts down the time of reaction from thirty days to just one day and gives up to 70% yield of bis(trifluoromethylthio)selenide (2) can prepared from hydrogen selenide and trifluoromethylsulfenyl chloride. The influence of other catalysts on the course of the reaction, the formation of unusual by-products, the NMR and the mass spectral data of 1 and 2 are presented ...
THE POTENT SYNTHETIC OPIATE FENTANYL CAN BE PREPARED BY REDUCTION OF AN INTERMEDIATE SCHIFF BASE OR BY DECYANATION OF A SUITABLE ALPHA-AMINONITRILE. IN THE MORE POTENT 3-METHYLFENTANYL SERIES, THE CIS- ISOMER IS MORE ACTIVE THAN THE TRANS- ISOMER. HENCE, AN ATTEMPT WAS MADE TO DEVELOP AN EFFICIENT STEREOSELECTIVE SYNTHESIS OF THE CIS-ISOMER. USING SODIUM BOROHYDRIDE, SUPER-HYDRIDE, RED-AL, AND L-SELECTRIDE, THE REDUCTION OF THE APPROPRIATE SCHIFF BASE, AND THE REDUCTIVE DECYANATION ...
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