Successful anti-tumor effects are weakened by removal of the tumor antigen pool (i.e. surgery) or use of cytoreductive and immunosuppressive therapies (i.e. chemotherapy and radiation). We hypothesize that mechanical disruption of the tumor in situ will augment immune responses due to antigen release. Iron particles were injected as magneto-rheological fluid (MRF) into an orthotopic primary breast cancer and followed by application of a magnetic field to exert force and shear ...
Magneto-rheological Fluid (MRF) is synthesized from suspensions of micron size iron particles in phosphate buffered saline (PBS). The iron particles are surface coated using atom transfer radical polymerization (ATRP) with various polymers, such as poly(N-isopropylacrylamide) (poly(NIPAAm)), and poly(acrylamide) (poly(AAm)). The surface grafted polymer has been characterized using differential scanning calorimetry (DSC), and properties of resulting fluid has been measured using a rheometer. A mathematical model is developed to explore the ...
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