During the three year grant period, efforts were focused on the relative contribution of cardiac (in addition to peripheral vascular) mechanisms to the frequency response characteristics of integrated cardiovascular regulation during time-dependent acceleration stress. To this end, our chronically instrumented animal preparation was enhanced to include cardiac denervation. In these animals, ultrasonic dimension crystals were also added for measuring left ventricular major and minor axis, wall thickness and calculated volume. ...
The research effort of the past year was divided into three phases, each of which adds to our systematic investigation of the frequency response characteristics of cardiovascular regulation. The frequency response characteristics are obtained from the analysis of pressure, flow and heart volume responses to low frequency, sinusoidal acceleration (0.001 to 0.25 Hz + or - 2gz). The 3 phases are: (1) Heart volume measurements in unblocked and autonomically blocked, ...
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