| Genetic Alterations in Epithelial and Stromal Compartments of Prostate Adenocarcinomas |
JAN 2004 |
11 pages |
| Authors:
Charis Eng; OHIO STATE UNIV COLUMBUS
|
 | Genetic analyses on prostate cancer has been occurring for over a decade. However, such studies were uniformly performed on the entire tumor without regard to its components despite the fact that a few groups were quite aware of both epithelial and stromal components of tumors, and the cell biology of the tumor "microenvironment" has been described for the last 20 years. Thus, until now, when a genetic alteration, be it ... |
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| A Novel Phosphatase Gene on 10q23, MINPP, in Hereditary and Sporadic Breast Cancer |
AUG 2003 |
49 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the P13 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
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| A Novel Phosphatase Gene on 10q23, MINNP, in Hereditary and Sporadic Breast Cancer |
AUG 2002 |
28 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the PI3 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
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| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 2001 |
66 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Germline mutations in PTEN on 10q23.3 cause 80% of classic Cowden syndrome (CS) and SO of Bannayan-Riley-Ruvalcaba syndrome (CS) as well as up to 20% of Proteus syndrome and up to 50 of unclassified Proteus-like syndromes. The major thrust of this grant was to identify and characterize PTEN's involvement in families and individuals with one ore more CS component tumors, of which prominently is breast cancer. During the funding period, ... |
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| A Novel Phosphatase Gene on 10q23, MINPP, in Hereditary and Sporadic Breast Cancer |
AUG 2001 |
19 pages |
| Authors:
Charis Eng; OHIO STATE UNIV COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the PI3 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
|
| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 1999 |
54 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Cowden syndrome (CS) is an autosomal dominant disorder characterized by multiple hamartomas and a high risk of breast, thyroid and other cancers. The susceptibility gene is PTEN. The edict of this grant is to determine the genetic role of PTEN in non-CS CS-like families or individuals. The PI has accrued 15 site specific breast cancer families, without known BRCA1 and BRCA2 mutations. No intragenic PTEN mutations were ... |
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