Proliferation and differentiation of normal breast epithelial cells are regulated by activation of the cellular tyrosine kinase machinery upon coordinated cellular stimulation through growth factor receptor tyrosine kinases and extra-cellular matrix receptor-induced activation of focal adhesion kinase FAK. This proposal is designed to investigate a novel hypothesis that Cbl provides, which has become established as a negative regulator of growth factor receptors, attenuates FAK-dependent growth signals in mammary epithelial cells. ...
Proliferation and differentiation of breast epithelial cells are regulated by the coordinated activation of the cellular tyrosine kinase machinery upon stimulation through growth factor receptors and extra-cellular matrix receptor-induced activation of focal adhesion kinase FAK. This proposal is designed to investigate a novel hypothesis that Cbl, a negative regulator of growth factor receptors, attenuates FAK-dependent growth signals in mammary epithelial cells. For this purpose, the Cbl interaction sites on FAK ...
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