Richard E. Dinterman - Storming Media

Treatment for Removal of Biotoxins from Drinking Water

SEP 93

Authors: Robert W. Wannemacher Jr.; Richard E. Dinterman; William L. Thompson; Mark O. Schmidt; W. D. Burrows; ARMY BIOMEDICAL RESEARCH AND DEVELOPMENT LAB FORT DETRICK MD

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The fate of biotoxins in water when subjected to Army field treatment technologies has been investigated. Near complete removal (more than 98 percent) of ricin, T-2, saxitoxin and microcystin was achieved by means of reverse osmosis, but coagulation/flocculation with ferric chloride was ineffective. Disappearance exceeded 99 percent for ricin and saxitoxin exposed to 100 mg/L free available chlorine for 30 minutes; lesser concentrations were ineffective, and the toxicities of T-2 ...

Characterization of Chemically Tritiated Microcystin-LR and Its Distribution in Mouse

14 FEB 89

23 pages

Authors: Nancy A. Robinson; George A. Miura; Charles F. Matson; Richard E. Dinterman; Judith G. Pace; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

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Chemically tritiated microcystin-LR (specific activity 194 mCi/mmol), purified to 95% by C-18 reverse-phase HPLC, exhibited the same retention time and ultraviolet absorption profile as unlabeled toxin. Acid-hydrolyzed 3H toxin yielded tritiated glutamate and beta-methylasparate. Stability of the nonexchangeable 3H toxin in saline and urine was 93% after 42 days stored at 22, 4, or -20 C. In blood the breakdown of toxin was temperature- and time-dependent (63% at 22 C, ...

The Hemostatic Derangement Produced by T-2 Toxin in Cynomolgus Monkeys

Authors: Thomas M. Cosgriff; David L. Bunner; Robert W. Wannemacher Jr.; Loreen A. Hodgson; Richard E. Dinterman; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

T-2 toxin, a mycotoxin produced by several strains of the genus Fusarium, has been implicated as a cause of serious illness in both animals and man. Hemorrhage is a feature of the syndromes which have been described. An LD20 dose of T-2 was administered intramuscularly to adult cynomolgus monkeys. This resulted in prolongation of prothrombin and activated partial thromboplastin times and a decrease in multiple coagulation factors. These changes were ...

Use of Lipid Calories during Pneumococcal Sepsis in the Rhesus Monkey,

22 NOV 1981

Authors: Robert W. Wannemacher Jr.; Mitchell V. Kaminski Jr.; Richard E. Dinterman; Thomas R. McCabe; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Phagocytosis and the Metabolic Sequelae of Infection

03 MAY 1979

Authors: Michael C. Powanda; Karen A. Bostian; Richard E. Dinterman; Wallace G. Fee; John P. Fowler; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Role of the Liver in Regulation of Ketone Body Production during Sepsis.

28 NOV 1978

Authors: Robert W. Wannemacher Jr.; Judith G. Pace; Francis A. Beall; Richard E. Dinterman; Vance J. Petrella; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

During caloric deprivation, the septic host may fail to develop ketonemia as an adaptation to starvation. Since the plasma ketone body concentration is a function of the ratio of hepatic production and peripheral utilization, a pneumococcal sepsis model was utilized in rats to measure the complex metabolic events that could account for this failure, including the effects of infection on lipolysis and esterification in adipose tissue, fatty acid transport in ...

Glucose and Alanine Metabolism During Bacterial Infections in Rats and Rhesus Monkeys,

02 AUG 1978

Authors: Robert W. Wannemacher Jr.; Franics A. Beall; Peter G. Canonico; Richard E. Dinterman; Clayton L. Hadick; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Protein Sparing Therapy during Pneumococcal Sepsis in Rhesus Monkeys.

25 APR 1978

Authors: Robert W. Wannemacher Jr.; Mitchell V. Kaminski Jr.; Harold A. Neufeld; Richard E. Dinterman; Karen A. Bostian; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

A model was developed in the rhesus monkey to determine if the marked wasting of body proteins associated with sepsis could be prevented by an intravenous supply of various nutritional substrates. All monkeys were given a basic infusion of 0.5 g of amino acid nitrogen/kg body weight via an indwelling catheter in the jugular vein. Three groups were given either no added calories, 85 cal/kg from dextrose, or 85 calories ...

The Role of Inflammation in Zinc, Amino Acid and Protein Alterations Induced by Zinc Chloride.

21 JUN 1977

Authors: Michael C. Powanda; Richard E. Dinterman; Edward C. Hauer; Philip Z. Sobocinski; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

The ip injection of zinc chloride (4-16 mg/kg) produces a curvilinear increase in plasma zinc concentration, a linear increase in liver zinc content, and an increase in the hepatic uptake of C(14) aminoisobutyrate which ar significantly greater than control values. This dose range of ZnCl2 also produces neutrophilia, increases in the plasma phenylalanine/tyrosine ratio and seromucoid and the appearance of alpha(2)-macrofetoprotein in the plasma, all of which are indicative of ...