The purpose of this study is to determine the safety and tolerability of topiramate (TPM) in the treatment of early seizures following traumatic brain injury (TBI) and to compare the efficacy of TPM to prevent early seizures to the standard of care (phenytoin). A secondary objective is to obtain the data necessary to design a randomized clinical trial to determine if TPM can prevent epilepsy and improve neurological outcome after ...
The purpose of this study is to determine the safety and tolerability of topiramate in the treatment of early seizures following traumatic brain injury (TBI), and to compare the efficacy of topiramate to prevent of early seizures to the standard of care (phenytoin). A secondary objective is to obtain data necessary to design of a randomized clinical trial to determine if topiramate can prevent epilepsy and improve neurological outcome after ...
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