Prostate cancer (PCa) continues to be the most frequently diagnosed cancer in men in the United States. The development of potent prevention strategies to diminish or eliminate this threat is in order and remains the long-term goal of this project. One possible etiologic factor in the development of PCa, is exposure to chronic oxidative stress, leading to the accumulation of potentially promutagenic oxidized DNA bases such as 8- hydroxydeoxyguanosine (8- ...
The overall objective of this award was to define novel, clinically- translatable strategies of prostate cancer (PCa) treatment based on the use of adenoviral vectors. Areas of overall research accomplishment during the award period have included development of a replication-restricted, PSA-selective oncolytic Ad5 vector (CV706) by incorporation of a minimal promoter enhancer construct (PSE) from the human PSA gene 5' of E1A. Demonstration of in vitro and in vivo anti-PCa ...
The development of potent prevention strategies to diminish the threat of prostate cancer (PCa) are in order and remains the long-term goal of this project. One possible etiologic factor in the development of PCa, is cellular exposure to chronic oxidative stress. Chronic oxidative damage can lead to the accumulation of potentially promutagenic oxidized DNA bases such as 8- hydroxydeoxyguanosine (8-OHdG). The detoxifying enzyme GSTP1 is inactivated in nearly 100%) of ...
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