This three-year randomized controlled trial is designed to assess the effectiveness of a comprehensive regimen incorporating strengthening and aerobic exercise in 14 ambulatory patients with spinal muscular atrophy (SMA). To date, 13 subjects have been screened and 5 subjects enrolled. Reasons for non-participation were most often cost and burden of travel. Protocol adherence has been outstanding thus far with only one deviation with regards to visit schedule. All testing and ...