| Captopril Modulates Hypoxia-Inducible Factors and Erythropoietin Responses in a Murine Model of Total Body Irradiation |
Jan 2011 |
14 pages |
| Authors:
Michal Barshishat-Kupper; Ognoon Mungunsukh; Ashlee J Tipton; Elizabeth A McCart; Ronald A Panganiban; Thomas A Davis; Michael R Landauer; Regina M Day; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF PHARMACOLOGY
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 | Objective. Our laboratory reported that the angiotensin converting enzyme inhibitor captopril improves erythroid recovery from total body irradiation (TBI) in mice when administered after irradiation. However, captopril administered before TBI attenuates erythroid recovery. Here we investigate captopril and radiation regulation of erythropoietin (EPO) and thrombopoietin (TPO), key effectors of erythroid progenitor proliferation and differentiation. Materials and Methods. C57BL/6 mice, nonirradiated or exposed to 7.5 Gy TBI (60Co, 0.6 Gy/min) were ... |
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| Hepatocyte Growth Factor Inhibits Apoptosis by the Profibrotic Factor Angiotensin II via Extracellular Signal-regulated Kinase 1/2 in Endothelial Cells and Tissue Explants |
01 Dec 2010 |
12 pages |
| Authors:
Young H Lee; Ana P Marquez; Ognoon Mungunsukh; Regina M Day; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF PHARMACOLOGY
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| Hepatocyte growth factor (HGF), an endogenous tissue repair factor, attenuates apoptosis in many primary cell types, but the mechanism is not completely understood. Our laboratory demonstrated that angiotensin (Ang) II activates the intrinsic apoptotic pathway in primary endothelial cells (ECs) via reduction of the antiapoptotic protein Bcl-xL. Ang II decreased Bcl-xL mRNA half-life by reducing its binding to nucleolin, a protein that normally binds a 3 AU-rich region and stabilizes ... |
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| Timing of Captopril Administration Determines Radiation Protection or Radiation Sensitization in a Murine Model of Total Body Irradiation |
Jan 2010 |
14 pages |
| Authors:
Thomas A Davis; Michael R Landauer; Steven R Mog; Michal Barshishat-Kupper; Stephen R Zins; Mihret F Amare; Regina M Day; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
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| Objective. Angiotensin II (Ang II), a potent vasoconstrictor, affects the growth and development of hematopoietic cells. Mixed findings have been reported for the effects of angiotensin-converting enzyme (ACE) inhibitors on radiation-induced injury to the hematopoietic system. We investigated the consequences of different regimens of the ACE inhibitor captopril on radiation-induced hematopoietic injury. Materials and Methods. C57BL/6 mice were either sham-irradiated or exposed to 60Co total body irradiation (0.6 Gy/min). Captopril ... |
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