| United States Army Research Institute of Environmental Medicine: Warfighter Research Focusing on the Past 25 Years |
Dec 2011 |
10 pages |
| Authors:
Kent B Pandolf; Ralph Francesconi; Michael N Sawka; Allen Cymerman; Reed W Hoyt; Andrew J Young; Edward J Zambraski; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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 | The United States Army Research Institute of Environmental Medicine (USARIEM) celebrated its 50th anniversary on July 1, 2011. This article reviews its history, evolution, and transition of its research programs as well as its scientific and military accomplishments, emphasizing the past 25 yr. During the 1990s, USARIEM published a series of pocket guides providing guidance for sustaining Warfighter health and performance in Southwest Asia, Somalia, the former Republic of Yugoslavia, ... |
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| Effect of Repeated Normobaric Hypoxia Exposures during Sleep on Acute Mountain Sickness, Exercise Performance, and Sleep during Exposure to Terrestrial Altitude |
2011 |
10 pages |
| Authors:
Charles S. Fulco; Stephen R. Muza; Beth A. Beidleman; Robby Demes; Janet E. Staab; Juli E. Jones; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| There is an expectation that repeated daily exposures to normobaric hypoxia (NH) will induce ventilatory acclimatization (VEacc) and be effective for lessening acute mountain sickness (AMS) and the exercise performance decrement during subsequent hypobaric hypoxia (HH) exposure. However, this notion has not been tested objectively. Healthy, unacclimatized sea level (SL) residents slept for 7.5 hrs each night for 7 consecutive nights in hypoxia rooms under either NH (n=14, 24+/-5 yr; ... |
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| The Impact of Moderate-Altitude Staging on Pulmonary Arterial Hemodynamics after Ascent to High Altitude |
Jan 2010 |
8 pages |
| Authors:
Aaron L Baggish; Charles S Fulco; Stephen Muza; Paul B Rock; Beth Beidleman; Allen Cymerman; Kibar Yared; Peter Fagenholz; David Systrom; Malissa J Wood; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Staged ascent (SA), temporary residence at moderate altitude en route to high altitude, reduces the incidence and severity of noncardiopulmonary altitude illness such as acute mountain sickness. To date, the impact of SA on pulmonary arterial pressure (PAP) is unknown. We tested the hypothesis that SA would attenuate the PAP increase that occurs during rapid, direct ascent (DA). Transthoracic echocardiography was used to estimate mean PAP in 10 healthy males ... |
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| Exercise Performance of Sea-Level Residents at 4300 m After 6 Days at 2200 m |
Nov-2009 |
8 pages |
| Authors:
Charles S Fulco; Stephen R Muza; Beth Beidleman; Juli Jones; Janet Staab; Paul B Rock; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Partial acclimatization resulting from staging at moderate altitude reduces acute mountain sickness during rapid exposure to higher altitudes (e.g., 4300 m). Whether staging also benefits endurance performance has not yet been scientifically evaluated. Purpose: Determine the effectiveness of staging at 2200 m on time trial (TT) performance of unacclimatized sea-level residents (SLR) during rapid exposure to 4300 m. There were 10 healthy men (mean +/- SE: 21 +/- 1 yrs) ... |
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| Effect of Six Days of Staging on Physiologic Adjustments and Acute Mountain Sickness During Ascent to 4300 Meters |
Jan 2009 |
9 pages |
| Authors:
Beth A Beldleman; Charles S Fulco; Stephen R Muza; Paul B Rock; Janet E Staab; Vincent A Forte; Michael D Brothers; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| This study determined the effectiveness of 6 days (d) of staging at 2200m on physiologic adjustments and acute mountain sickness (AMS) during rapid, high-risk ascent to 4300m. Eleven sea-level (SL) resident men (means +SD; 21+3 yr; 78+13 kg) completed resting measures of end-tidal CO2 (Petco2), arterial oxygen saturation (Sao2), heart rate (HR), and mean arterial pressure (MAP) at SL and within 1 h of exposure to 4300m in a hypobaric ... |
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| Living for Six Days at 2200 M Improves Time-Trial Performance of Sea-Level Residents Exposed to 4300 M |
FEB 2008 |
30 pages |
| Authors:
Charles S. Fulco; Stephen R. Muza; Beth Beidleman; Juli Jones; Eric Lammi; Janet Staab; Paul B. Rock; Kenneth Kambis; Ellen Glickman; Brandon K. Doan; Michael D. Brothers; Michael F. Zupan; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| The overall objective of the current project was to determine in previously unacclimatized SLR the effectiveness of staging in minimizing impairments in physical and cognitive performances and reducing acute mountain sickness incidence and severity during subsequent high altitude exposure The data presented here will be focused on the effects of staging at moderate altitude on prolonged endurance performance of SLR during exposure to 4300 m The results from the current ... |
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| Hemoglobin P50 During a Simulated Ascent of Mt. Everest, Operation Everest II |
2007 |
12 pages |
| Authors:
Peter D. Wagner; Harrieth E. Wagner; Bertron M. Groves; Allen Cymerman; Charles S. Houston; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA MILITARY NUTRITION DIV
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| The amount of O2 available to tissues is essentially the product of cardiac output, [Hb], and O2 saturation. Saturation depends on P(O2) and the O2Hb dissociation curve. With altitude, increased [2,3-DPG] shifts the dissociation curve rightward, but hypocapnia and alkalosis move it leftward. We determined both standard and in vivo P(50) in 5 fit subjects decompressed over 42 days in an altitude chamber to the equivalent of the Mt. Everest ... |
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| Maintaining Enduance Performance at High Altitude (4300 m) Despite Severe Energy Intake Deficit |
NOV 2006 |
21 pages |
| Authors:
Charles S. Fulco; Stephen R. Muza; Anne L. Friedlander; Paul B. Rock; Barry Braun; Carol J. Baker-Fulco; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Body weight (BW) and lean body mass (LBM) of sea-level (SL) residents are typically reduced by < 4% and < 2%, respectively, while endurance performance is greatly impaired initially but then improves during the first 3 weeks of altitude exposure. This purpose of this study was to determine if a greater reduction is LBM due to severe energy intake deficit will eliminate the performance improvement despite maintenance of a high ... |
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| Validation of a Shortened Electronic Version of the Environmental Symptoms Questionnaire |
NOV 2006 |
18 pages |
| Authors:
Beth A. Beidleman; Stephen R. Muza; Charles S. Fulco; Paul B. Rock; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Acute Mountain Sickness (AMS) is a syndrome that is characterized by headache, insomnia, anorexia, nausea, dizziness, and fatigue, but without abnormal neurological findings (11, 22). The severity and incidence of AMS is primarily related to the initial altitude, the rate of ascent, the altitude reached, and the duration of exposure to altitude (9, 13, 16, 21, 30). Additional factors that affect the severity and incidence of AMS are the degree ... |
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| Effect of High Altitude Exposure, Antioxidant Supplementation, and Exercise on Postural Stability |
JUL 2006 |
29 pages |
| Authors:
Allen Cymerman; Kimberly Stone; Anne L. Friedlander; Stephen R. Muza; Charles S. Fulco; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Hypoxia caused by rapid travel to high mountain areas can have devastating effects on the health and performance of sensitive individuals. To better understand the factors involved in these detrimental effects, in 2002, the Palo Alto Veterans Affairs Hospital (PAVA) and the United States Army Research Institute of Environmental Medicine (USARIEM) culminated a 3-yr study entitled "Effect of energy deficit on work performance at 4,300 m elevation." The overall goal ... |
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| Changes in Ventilatory Threshold at High Altitude: Effect of Antioxidants |
2006 |
8 pages |
| Authors:
Andrew W. Subudhi; Kevin A. Jacobs; Todd A. Hagobian; Jill A. Fattor; Charles S. Fulco; Allen Cymerman; Anne L. Friedlander; COLORADO UNIV AT COLORADO SPRINGS
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| To investigate the effects of prolonged hypoxia and antioxidant supplementation on ventilatory threshold(VT) during high-altitude(HA) exposure (4300M). Methods: Sixteen physically fit male (25 + 5, 77.8 + 8.5 kg) performed an incremental test to maximal exertion on a cycle ergometer at sea level (SL) |
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| Effect of Acetazolamide on Leg Endurance Exercise at Sea Level and Simulated Altitude |
2006 |
11 pages |
| Authors:
Charles S. Fulco; Steven R. Muza; Dan Ditzler; Eric Lammi; Steven F. Lewis; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Acetazolamide can be taken at sea level to prevent acute mountain sickness during subsequent altitude exposure. Acetazolamide causes metabolic acidosis at sea level and altitude, and increase Sao2 (arterial oxygen saturation) at altitude. The aim of the present study was to determine whether acetazolamide impairs muscle endurance at sea level but not simulated altitude (4300 m for |
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| Intermittent Altitude Exposures Reduce Acute Mountain Sickness at 4300 M |
JAN 2004 |
9 pages |
| Authors:
Beth A. Beidleman; Stephen R. Muza; Charles S. Fulco; Allen Cymerman; Dan Ditzler; Dean Stulz; Janet E. Staab; Gary S. Skrinar; Steven F. Lewis; Michael N. Sawka; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Acute mountain sickness (AMS) commonly occurs at altitudes exceeding 2000-2500 m and usually resolves after acclimatization induced by a few days of chronic residence at the same altitude. Increased ventilation and diuresis may contribute to the reduction in AMS with altitude acclimatization. The aim of the present study was to examine the effects of intermittent altitude exposures (IAE), in combination with rest and exercise training, on the incidence and severity ... |
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| Operation Everest II: Comparison of Four Instruments for Measuring Blood O2 Saturation |
Jan 1989 |
6 pages |
| Authors:
Forte; Vincent A Jr; Mark K Malconian; Richard L Burse; Paul B Rock; Patricia M Young; Laurie A Trad; Bruce A Ruscio; John R Sutton; Charles S Houston; Allen Cymerman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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| The bias and precision of four different methods for determining O2 saturation (So2) were evaluated during a study of hypobaric hypoxia conducted with seven male subjects exposed progressively over a 40-day period to simulated altitudes from sea level (760 Torr) to 8,840 m (240 Torr). So2 of arterial and mixed venous blood samples were measured with the Instrumentation Laboratory 282 CO-oximeter (CO-OX), the Radiometer ABL-300 (ABL), and the Lex-O2-Con-K (LEX). ... |
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| Perception of Effort during Constant Work to Self-Imposed Exhaustion |
22 DEC 1977 |
27 pages |
| Authors:
Donald H. Horstman; William P. Morgan; Allen Cymerman; James Stokes; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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| This study describes the pattern of change in effort sense and the value of this pattern in predicting work end point at relatively high work intensity (80% VO2 max). Patterns of change of various physiological functions were also observed. Two modes of work (walking and running) were compared to ascertain generalizability of results. Subjects were 26 healthy male volunteers. Time to exhaustion (ET) did not differ between walking and running. ... |
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