The hygiene hypothesis , the idea that reduced exposure to important microbes, especially in childhood, impacts development of asthma and allergies, may have application to breast cancer. This research project aims to explore the hygiene hypothesis as it might relate to breast cancer development, thereby assessing its utility for more comprehensive future research. This research project is aiming to interview a population-based series of 500 Californian women recently diagnosed with ...
As both breast cancer incidence and the highly polymorphic genes for the human leukocyte antigen (HLA) component of the immune system differ across racial/ethnic groups, HLA may be a biologically based risk factor for breast cancer and explain some of its racial/ethnic variation. In a population-based series of 915 post-menopausal white, black and Hispanic breast cancer cases and controls, we determined HLA class I (A, B) and class II (DR, ...
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