Underlying mechanisms that account for the increased risk of aggressive, metastatic disease associated with basal type breast cancers compared to the more differentiated, luminal tumor subtype have not been well established. Our work demonstrates that the transcription factor GATA3, essential for luminal differentiation during mammary gland development, is sufficient to promote global changes in basal triple-negative breast cancer (BTNBC) cells resulting in both 1) reduced metastasis via LOX downregulation and ...
Breast cancer is the most frequent cancer in women. On third of new breast cancers do not express estrogen receptor (ER) protein and these have a worse prognosis than ER positive breast cancers. The ER is a ligand activated transcription factor. Estrogen:ER binding stimulates rapid Src activation that feeds back to phosphorylate the ER and increases its transcriptional activity. Estrogen binding to the ER rapidly activates ubiquitin-dependent ER proteolysis which ...
Estrogen regulates the proliferation and development of tissues expressing estrogen receptors and is implicated as a risk factor for the development of breast cancer. One third of new breast cancers do not express estrogen receptor (ER) protein and these have a worse prognosis than ER positive breast cancers. Here we investigated how mechanisms underlying the reduced ER protein in ER negative cancers may be linked to their aggressive behavior. Estrogen ...
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