Metastasis to bone is a major cause of morbidity from prostate cancer. Parathyroid hormone related protein (PTHrP) is expressed by prostate cancer cells and stimulates osteoclasts. My project to test whether an antibody against PTHrP will block prostate cancer metastasis to bone. I clone the light and heavy chain cDNAs from a hybridoma, which secretes a PTHrP-neutralizing antibody which blocks breast cancer metastasis to bone but is untested against prostate ...
Autocrine motility factor (AM F) is expressed by human breast cancer cells, such as MCF7 where its expression is stimulated by heregulin. Tumor cells constitutively secreting mouse AMF caused periosteal new bone formation in two different models of metastasis-an osteoblastic response similar to what is found with about 15% of breast cancers metastatic to bone. Whenever serum AMF concentrations were significantly increased, the animals displayed tumor- associated weight loss (cachexia), ...
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