The purpose of this research is to determine which steps in the metastatic process are affected by the metastasis suppressor gene, BRMS1. Stable b-Gal expressing MDA-MB-231 and MDA-MB-231/BRMS1 cell lines were used to identify 2 steps in the metastatic process inhibited by BRMS1. It was found that BRMS1-expression (I) reduced the numbers of solitary cells that survive initial arrest in the lung (4 hours) and (2) reduced the numbers of ...
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