Richard Bull - Storming Media

DCA Dosimetry: Interpreting DCA- Induced Liver Cancer Dose Response and the Potential for DCA to Contribute to TCE-Induced Liver Cancer

APR 1998

30 pages

Authors: Melvin E. Andersen; Hugh A. Barton; Richard Bull; Irving Schultz; BATTELLE PACIFIC NORTHWEST LABS RICHLAND WA

The full text of this report is available for sale.

The contribution of TCE-derived DCA to the induction of hepatocellular carcinoma in the mouse liver bioassay has been a pivotal issue in assessing the risk associated with oral exposure to TCE. The goal of this study was to investigate the biological plausibility of the hypothesis that TCE- derived DCA contributed significantly to TCE-induced mouse liver cancer. A pharmacokinetic analysis for DCA in naive and DCA-pretreated mice has been conducted in ...