| Effects of Postmortem Freezing on Passive Properties of Rabbit Extensor Digtorum Longus Muscle Tendon Complex |
14 JUN 93 |
18 pages |
| Authors:
Paul H. Leitschuh; Tammy J. Doherty; Dean C. Taylor; Daniel E. Brooks; John B. Ryan; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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 | The tensile properties of the extensor digitorum longus muscle tendon unit (EDL MTU) were studied in 16 white male New Zealand rabbits in the freshly euthanized state (less than 30 minutes after death) and the frozen-thawed state (frozen at -80 deg C for 28 days and then warmed to 38 deg C) Stretch to failure was specifically analyzed. Frozen thawed EDL MTUs had significantly lower ultimate force to failure (p<.01), ... |
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| Effect of Storage on Oxygen Transport in Blood Obtained from Man, Dog and Monkey. |
16 APR 1974 |
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| Authors:
Charles E. Shields; David E. Meixner; Joseph F. Bratton; Daniel E. Brooks; Angelo I. Zegna; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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 | Red cells obtained from human, monkey and canine subjects were stored in acid-citrate-dextrose (ACD) over a six week period and periodically tested for mid saturation point (P50), pH, adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (DPG) levels. In addition, blood obtained from dogs kept chronically anemic and also from those undergoing daily exercise was stored and compared to the other groups. The anemic and exercised groups were found to have higher than ... |
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| Oxygen Transport Changes During Replacement with Stored Blood in a Hemorrhagic Canine Model. |
04 MAR 1974 |
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| Authors:
Charles E. Shields; David E. Meixner; Joseph F. Bratton; Daniel E. Brooks; Garry C. Phillips; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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| Healthy beagles were bled 30% of their estimated blood volume and maintained in this low blood pressure state for a finite period and then transfused with blood stored for 14, 28 or 42 days. Blood samples from the stored units and before and after transfusion were analyzed for oxygen function changes indicate by shifts in P50, 2, 3 diphosphoglycerate levels, as well as testing for adenosine triphosphate (ATP) and plasma ... |
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| Changes in Red Cell P50 and Survival in Stored and Transfused ACD Dog Blood. |
02 NOV 1973 |
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| Authors:
Charles E. Shields; Angelo I. Zegna; Joseph F. Bratton; David E. Meixner; Daniel E. Brooks; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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| Blood stored in acid-citrate dextrose (ACD) for varying time periods was studied for effect on survival and oxygen transport. The units were transfused in 50 ml volumes so that each unit was paired with one recipient being the original donor, and the other a compatible subject. Survival values determined 24 hours after transfusion showed gradual decline with length of storage. A shift to the left in the oxygen dissociation curve, ... |
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| 'In vitro' Effect of Adenine on Stored Canine and Human Blood. |
31 OCT 1973 |
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| Authors:
Charles E. Shields; David E. Meixner; Joseph F. Bratton; Daniel E. Brooks; Garry C. Phillips; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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| Human and dog red cells stored for six weeks in high concentrations of adenine equivalent to 25 or 50 mg/kg body weight were found to show decreased pH, P50, and diphosphoglycerate (DPG) levels comparable to other studies. A decrease in adenosine triphosphates (ATP) with storage was observed; however, there was a higher level with greater adenine doses indicating support of the ATP level by the adenine. No signs of toxic ... |
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| Studies of Dogs Subjected to Acute Blood Loss and Transfused with Blood Stored in ACD with and without Adenine. |
30 OCT 1973 |
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| Authors:
Charles E. Shields; Angelo I. Zegna; David E. Meixner; Joseph F. Bratton; Daniel E. Brooks; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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| Transfusion of stored blood after acute hemorrhage in a canine experimental model was observed. The transfused blood had been stored in acid-citrate-dextrose with or without adenine for 14, 28, or 42 days. Diphosphoglycerate, adenosine triphosphate, and pH levels decreased with storage, while the oxygen curve shift to the left was indicated by the decrease in P50. After transfusion, low values of diphosphoglycerate and P50 were observed in the recipient, but ... |
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| Rapid Disappearance of Radiochromium-Labeled Erythrocytes Immediately After Transfusion in Dogs. |
04 SEP 1973 |
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| Authors:
Charles E. Shields; Angelo I. Zegna; David E. Meixner; Michael L. Sampson; Daniel E. Brooks; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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| Canine recipients received transfusions of fresh autologous or homologous cells stored for varying periods of time. These cells had been labeled with 51Cr and transfused at a controlled rate within the same time frame. Radioactivity was measured serially during the 20 min after transfusion and then daily. All subjects showed an initial rapid decrease in radioactivity in the first 20 min, which was significantly more rapid with stored cells. Follow-up ... |
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