| Effects of Organophosphorus Agents on Performance |
29 OCT 86 |
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| Authors:
Henry E. Brezenoff; Norman Hymowitz; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK
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 | Rats were trained to press a lever under a multiple schedule of food or water reinforcement. Food-maintained response rates were reduced due to peripheral factors by atropine and methylatropine, while the selective central muscarinic antagonist N-(diethylamino-2-butynyl) succinimide (DKJ-21) had little effect. The AChE inhibitor physostigmine suppressed responding maintained under food reinforcement. DKJ-21, but atropine, was an effective antagonist of the rate-suppressing effect of physostigmine. Intraperitoneal (i.p.) administration of soman (5-40 ... |
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| Cardiovascular Effects of Soman |
15 APR 86 |
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| Authors:
Henry E. Brezenoff; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK
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| Soman, sarin, and DFP all produced a rise in blood pressure when injected into the cerebral ventricles of the rat. The order of potency was similar to that following i.v. administration, i.e., soman > sarin > DFP. This confirms that the difference in potency does not involve differences in absorption through the blood brain barrier. The more gradual onset and development of the pressor response to DFP appears to be ... |
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| Effects of Organophosphorous Agents on Performance |
DEC 84 |
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| Authors:
Henry E. Brezenoff; Norman Hymowitz; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK
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| Rats were trained to press a lever under a multiple schedule of food or water reinforcement. The muscarinic antagonists atropine and methylatropine, but not the selective central muscarinic antagonist DKJ-21, reduced response rates in rats maintained under schedules of food delivery. The suppression produced by atropine and methylatropine appears to be due to peripheral factors, most likely dry mouth. In contrast, both atropine and DKJ-21 reduced water- maintained response rates, ... |
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| Hypertensive Effect of Brain Acetylcholinesterase Inhibition |
08 MAR 1982 |
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| Authors:
Henry E. Brezenoff; NEW JERSEY MEDICAL SCHOOL NEWARK
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| Lethal or near-lethal doses of acetylcholinesterase (AChE) inhibitors cause respiratory depression and cardiovascular collapse. Lower doses, however, evoke a centrally-mediated increase in blood pressure. This hypertensive response occurs in a variety of animal species, including humans. The overall objective of this project was to study the central mechanisms involved in the pressor effect of AChE inhibitors and to determine the role of brain acetylcholine (ACh) in hypertensive states. To that ... |
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| Modulatory Effect on Brain Acetylcholine on Reflex-Induced Bradycardia and Tachycardia in Conscious Rats, |
25 MAR 1980 |
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| Authors:
A. P. Caputi; F. Rossi; K. Carney; Henry E. Brezenoff; NEW JERSEY MEDICAL SCHOOL NEWARK DEPT OF PHARMACOLOGY
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| Age-Related Hypotensive Effect of Atropine in Unanesthetized Spontaneously Hypertensive Rats, |
16 JAN 1980 |
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| Authors:
Achille P. Caputi; Bruce H. Camilleri; Henry E. Brezenoff; NEW JERSEY MEDICAL SCHOOL NEWARK DEPT OF PHARMACOLOGY
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| The Role of Angiotensin in the Pressor Response to Propranolol and the Hypotensive Response to Phentolamine, |
1980 |
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| Authors:
Henry E. Brezenoff; B. Camilleri; NEW JERSEY MEDICAL SCHOOL NEWARK DEPT OF PHARMACOLOGY
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| Chemical, physical and mechanical analyses were used to characterize the effects of hydrothermal exposure on graphite fiber reinforced epoxy matrix composites. Nondestructive analysis of moisture diffusion kinetics and ultrasonic response shows that strength degradation is dominated by matrix bulk properties. Comparative chemical analysis of two catalytically cured graphite/epoxy composites and an aromatic amine cured epoxy matrix clearly showed that curing mechanisms and epoxy network structure influence thermal response and environmental ... |
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