Dextromethorphan is an antitussive compound with anticonvulsant and neuroprotective properties arising from actions within the central nervous system of mammals. In the present study we have determined the distribution of 3H-dextromethorphan (3HJ-DM) binding sites in normal rat brain and 72 hours after middle cerebral artery occlusion. The pattern of distribution did not correlate with that of the excitatory amino acid, N-methyl-D-aspartate (NMDA), with which an association has previously been suggested ...
A study has been carried out in the rat middle cerebral artery occlusion model with dextromethorphan, carbetapentane and three of the carbetapentane analogues, 11, B and D, which were previously examined in the (3H)dextromethorphan and (3H)TCP binding assays.
Binding of dextromethorphan and its analogues to the dextromethorphan binding site and to the PCP and glycine binding sites associated with the N- methyl-D-aspartate receptor-channel complex was investigated using 3H-DM, H-TCP and 3H-glycine as radioligands. The experiments were carried out in 1m1 tubes (miniblocks), in a final incubation volume of 0.5m1. All reagents were diluted and dispensed using a TECAN and filtering was done using a Brandel M-48R. Samples were ...
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