We are developing small, robust catalytic systems to efficiently degrade DNA/RNA with a high degree of specificity. Here, we describe the use of tetra-azamacrocyle-chelated Co(III) complexes for the effective hydrolysis of double stranded plasmid DNA. These chelator molecules have been functionalized with a coupling group and we examine whether the modification has affected the ability of the complex to degrade DNA. Hydrolysis of DNA does appear to be slowed by ...
Objective: Develop strongly binding artificial nucleases, with enhanced sequence-recognition and stability for anti-bacterial and anti-viral applications. Approach: Synthesize small metal-chelator complexes suitably modified for coupling to oligonucleotides (ODN) as nuclease-like probes for binding to target viral RNA sequences.
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