Both rat oral (intubation) and rabbit dermal toxicity tests were conducted with various VX-waste stream products according to established DoT (49 CFR) procedures. The Super Critical Water Oxidation (SCWO) distillate sample produced no observable toxic effects in either rats or rabbits. A VX/NaOH reaction product (M12-02-05-VT-0358) produced severe dermal irritation to include necrosis to intact rabbit skin and gastric necrosis in rats dosed orally. No ...
The research described in this study is part of the continued support to the Alternative Technology Program's search for the optimum procedure to demilitarize the chemical agent, VX, in lieu of incineration. This report is a summary of data from 11 samples of demiled VX tested in mice by the intravenous route to determine their toxicity. Toxicity (24-hr LD50s) ranged from 32.3-10, 306 mg/kg. The historical ...
The intravenous toxicity of VX decontamination by-products was determined in young adult male Institute of Cancer Research (ICR) mice. The Alternative Technology Program was tasked to investigate/search for methods other than incineration to effectively neutralize agent VX. The intravenous toxicity (LD50) of the 14 materials tested ranged from 26.5 - >10,684.0 mg/kg. The original starting material, VX, historically has an intravenous LD50 in mice of about 0.0141 mg/kg. Therefore, the ...
Six samples of mustard (HD) were decontaminated using water with additional degrading by bioreactions. These materials were tested dermally in adult New Zealand White (NZW) rabbits at 1.0 ML/kg to assess their dermal irritation hazard. Results indicate that all six decontaminated!HD!water by- products no longer possessed dermal irritancy properties. A control 1.0% HD/PEG- 200 sample produced severe dermal irritation in all 12 rabbits tested. A control sample of thiodiglycol produced ...
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