Antibodies to the circumsporozoite (CS) protein may play a role in the protective immunity induced by immunization with irradiated sporozoites. However, the observation that protection against a large (5000 sporozoites) inoculum is dependent on T cells of the suppressor/cytotoxic phenotype (CD8) has clearly established the importance of cellular mechanisms in this model system. In an attempt to stimulate a protective cellular immune response, Balb/CByJ mice were immunized intraperitoneally with one ...
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