| Oxidative Damage in Parkinson's Disease |
JAN 2005 |
86 pages |
| Authors:
M. F. Beal; MASSACHUSETTS GENERAL HOSPITAL BOSTON
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 | The overall goal of the proposal was to provide a detailed assessment of the role of oxidative damage in Parkinson's disease (PD) and the MPTP model of PD. During our one year addendum, we carried out studies which showed the anti-inflammatory agent minocycline exacerbated MPTP neurotoxicity. The anti- inflammatory compound rolipram produced dose-dependent neuroprotective effects against MPTP. Administration of the iron chelator clioquinol was neuroprotective against MPTP and this was ... |
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| Oxidative Damage in Parkinson's Disease |
JAN 2003 |
21 pages |
| Authors:
M. F. Beal; CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
|
| The overall goal of the proposal was to provide a detailed assessment of the role of oxidative damage in Parkinson's Disease (PD) postmortem brain tissue, body fluids of PD patients and in the MPTP model. There were trends towards increased oxidative damage markers in post mortem brain tissue of PD patients and a number of specific genes linked to oxidative stress were reduced in expression. There was increased lipid peroxidation ... |
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| Oxidative Damage in Parkinson's Disease |
OCT 2001 |
60 pages |
| Authors:
M. F. Beal; CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
|
| The objective of the present research is to determine whether there is a coherent body of evidence implicating oxidative damage in the pathogenesis of Parkinson's Disease and the MPTP model of Parkinsonism. In the past year, we have developed a novel column switching assay for measurement of oxidative damage to DNA in human body fluids. We have applied to this plasma samples of Parkinson's Disease patients. We have also developed ... |
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| Oxidative Damage in Parkinson's Disease |
OCT 2000 |
49 pages |
| Authors:
M. F. Beal; CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
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| The objective of the present research is to determine whether there is a coherent body of evidence implicating oxidative damage in the pathogenesis of Parkinson's Disease and the MPTP model of Parkinsonism. We found that there are significant decreases in alpha-ketoglutarate dehydrogenase complex and a significant increase in tissue malondialdehyde levels in the superior frontal cortex, the Parkinsonian syndrome known as Progressive Supranuclear Palsy. We are continuing studies looking at ... |
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| Oxidative Damage in Parkinson's Disease |
OCT 1999 |
100 pages |
| Authors:
M. F. Beal; Ann B. Young; MASSACHUSETTS GENERAL HOSPITAL BOSTON
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| The objective of the present research is to determine whether there is a coherent body of evidence implicating oxidative damage in the pathogenesis of Parkinson's Disease and the MPTP model of Parkinsonism. We carried out initial studies in the Parkinsonian Syndrome known as Progressive Supranuclear Palsy. These studies showed that there is significant increase in lipid peroxidation in the subthalamic nucleus. We developed a novel ... |
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