Ronald E. Baynes - Storming Media

Quantitating the Percutaneous Absorption of Mechanistically-Defined Chemical Mixtures

03 MAY 2004

33 pages

Authors: Jim E. Riviere; Nancy A. Monteiro-Riviere; Ronald E. Baynes; Xin-Rui Xia; Charles Smith; NORTH CAROLINA STATE UNIV AT RALEIGH SCHOOL OF VETERINARY MEDICINE

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The focus of this research was to assess the dermal absorption and skin toxicity of topically applied jet fuels Jet A, JP-8, JP-8(100) using pigs, in vitro porcine skin and inert membrane models as well as human keratinocyte cell cultures. Our working hypothesis was that jet fuel dermal toxicity was secondary to its hydrocarbon components with differences between fuel types due to additive-modulation of hydrocarbon deposition. Consistent with previous JP-8 ...

Quantitating the Percutaneous Absorption of Mechanistically Defined Chemical Mixtures

02 FEB 2001

109 pages

Authors: Jim E. Riviere; Ronald E. Baynes; Charles Smith; NORTH CAROLINA STATE UNIV AT RALEIGH CUTANEOUS PHARMACOLOGY AND TOXICOLOGY CENTER

The focus of this research was to assess the percutaneous absorption and cutaneous toxicity of jet fuels (Jet A, JP-8, JP-8 +100). The absorption of jet fuel hydrocarbons (naphthalene, dodecane, hexadecane) was studied as a function of jet fuel type and the presence of individual or all possible combinations of performance additives (DIEGME, 8Q2l, Stadis 450). Percutaneous absorption was investigated using in vitro flow-through diffusion cells containing inert silastic or ...

Percutaneous Absorption of Chemical Mixture Relevant to the Gulf War

FEB 2001

Authors: Jim E. Riviere; Nancy A. Monteiro-Riviere; Ronald E. Baynes; NORTH CAROLINA STATE UNIV AT RALEIGH

The full text of this report is not available and therefore is not for sale. This information is provided for reference purposes only.

The purpose of this research is to quantitate the dermal absorption and cutaneous toxicity of chemical mixtures relevant to the Gulf War. The primary focus of year 2 of this proposal was to assess 1) the effect that systemic exposure to pyridostigmine bromide (PB) has on DEBT and permethrin absorption; 2.) the effect of topical and systemic exposure of DFP (CW nerve agent simulant) on absorption of these chemicals, and ...