| The Use of ATP-MgCl2 in the Treatment of Injury and Shock |
31 JUL 86 |
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| Authors:
Arthur E. Baue; Irshad Chaudry; YALE UNIV NEW HAVEN CONN DEPT OF SURGERY
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 | The purpose of our study was to determine how ATP-Magnesium Chloride might be used, what the potential problems with ATP-MGCL2 might be and to develop all the necessary background information in order to initiate clinical trials. In normal as well as hypovelemic awake dogs, cardiac output can be increased significantly by infusion of ATP-MGL2 intravenously at rates of 0.5-2. 5 mg/Kg/min. Although higher doses of S4ATP-MgL2 may have detrimental hemodynamic ... |
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| The Use of ATP-MgCl2 in the Treatment of Injury and Shock |
11 MAR 86 |
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| Authors:
Arthur E. Baue; Irshad H. Chaudry; YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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| Studies were conducted to compare the effects of positive end- expiratory pressure (PEEP) and zero end-expiratory pressure (ZEEP) in experimentally induced Pseudomonas pneumonia. Our results indicated a conspicuous advantage of PEEP over ZEEP in experimentally-induced Pseudomonas pneumonia, not only in terms of improved cardiopulmonary function but also in terms of survival. The mechanisms by which PEEP improves the survival of dogs with Pseudomonas pneumonia may be due to an improvement ... |
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| The Use of ATP-MgCl2 in the Treatment of Injury and Shock |
30 JAN 85 |
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| Authors:
Arthur E. Baue; Irshad H. Chaudry; YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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| The purpose of our studies was to determine the hemodynamic responses to ATP-Magnesium chloride (MgC12) in conscious dogs and primates. ATP-MgC12 infusion into normovolemic and hypovolemic dogs produced a decrease in systemic vascular resistance, an increase in cardiac output and a decrease in heart rate. This combination of effects would be particularly beneficial to the hypovolemic patient. Our objectives were to also determine the safety and hemodynamic response of ATP-MgC12 ... |
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| Alterations in Tissue Metabolism with Injury and Shock. |
NOV 1978 |
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| Authors:
Arthur E. Baue; Irshad H. Chaudry; YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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| Our studies have shown that infusion of ATP-MGCl2 following 60 to 90 minutes of hepatic ischemia improved hepatic function, cellular architecture and improved the survival of animals. To the best of our knowledge, this is the first demonstration that an agent has proved successful in the treatment of post-ischemic hepatic failure. Our results have also shown that infusion of ATP-MgCl2 following a severe renal insult significantly improved both glomerular and ... |
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| Alterations in Tissue Metabolism (The Lung) with Injury and Shock. |
30 SEP 1976 |
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| Authors:
Arthur E. Baue; YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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| The results indicate that the extent to which tissue ATP levels decreased during shock may be related to the metabolic activity of the organ or tissue. Associated with the decrease of tissue ATP levels was a decrease in tissue cyclic AMP levels. The results also indicate that the ability of tissue to regenerate ATP is markedly decreased during shock. Basal gluconeogenesis was unaltered during shock and steroids were found to ... |
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| Alterations in Tissue Metabolism (The Lung) with Injury and Shock. |
15 JUL 1975 |
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| Authors:
Arthur E. Baue; WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
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| With circulatory failure in various organs, particularly the liver, kidney and muscle, the initial change is an alteration in the membrane of the cell with the decreased cell membrane potential and with an alteration in cation transport and in responsiveness to various hormonal substances. Sodium then tends to enter the cell, water also enters, potassium tends to leak out, Na(+) + K(+) -ATPase is activated, ATP is progressively used up, ... |
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| Alterations in Tissue Metabolism (The Lung) with Injury and Shock. |
15 JUL 1975 |
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| Authors:
Arthur E. Baue; WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
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| Alterations in Tissue Metabolism (The Lung) with Injury and Shock. |
15 JUL 1974 |
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| Authors:
Arthur E. Baue; JEWISH HOSPITAL ST LOUIS MO
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| Alterations in Tissue Metabolism (The Lung) with Injury and Shock. |
15 JUL 1973 |
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| Authors:
Arthur E. Baue; WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
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| Alterations in cell function during shock with decreased mitochondrial metabolic capability, increased ATPase activity and increased mitochondrial Na and decreased K have all been corrected by treatment. These changes and decreased ATP levels in cells have suggested possible impairment of the ability of cell membranes to carry out active transport and maintain cell volume. The present studies were carried out to measure cell membrane transport during and after shock. (Author) ... |
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| Alterations in Tissue Metabolism (The Lung) with Injury and Shock. |
15 JUL 1972 |
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| Authors:
Arthur E. Baue; WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
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| In a short period of time a number of changes were found to occurr in cells with shock which are progressive. These are original observations which are now being confirmed by other investigators. These changes are related to other things which are occurring in the cell and affect organ failure. This is now beginning to lead to study of treatment programs and influence depressed cell function. A more coherent story ... |
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| Alterations in Tissue Metabolism (the Lung) with Injury and Shock. |
15 JUL 1971 |
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| Authors:
Arthur E. Baue; JEWISH HOSPITAL ST LOUIS MO
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| The purpose of work carried out under this contract was to investigate cellular injury with shock, particularly as it might relate to organ failure and death in combat casualties. Particular emphasis was placed upon the lung because of the problem of ventilatory or respiratory failure after severe injury which has been encountered in Vietnam. Details of the studies of cells and cell metabolism in shock centered initially about three tissues ... |
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Reports by Author
