| Breast Tumor/Stromal Cell Interaction in Bone |
JUL 2004 |
41 pages |
| Authors:
Normand Pouliot; Robin L. Anderson; PETER MACCALLUM CANCER INST MELBOURNE (AUSTRALIA)
|
 | Breast cancer is a leading cause of cancer mortality among western women. The high incidence of metastatic spread of breast tumors to bone in these women is, for the vast majority, associated with osteolytic lesions leading to significant clinical complications including osteoporosis, hypercalcemia, intractable pain, spinal cord compression and fracture of the long bones that invariably impair the quality of life of those affected (reviewed in (1)). Whilst the mechanisms ... |
|
| Stromal Gene Expression and Function in Primary Breast Tumors that Metastasize to Bone Cancer |
JUL 2004 |
26 pages |
| Authors:
Belinda Parker; Robin L. Anderson; MELBOURNE UNIV VICTORIA (AUSTRALIA)
|
| A clinically relevant syngeneic model of breast cancer metastasis has been used to determine gene expression alterations that occur both between primary breast cancers with varying metastatic potential and between matched primary and bone metastases. We have immunopurified epithelial and endothelial cell populations and profiled them separately to identify differentially expressed genes, some of which have not previously been associated with breast cancer metastasis. Expression profiles of vascular endothelium derived ... |
|
| Breast Tumor/Stromal Cell Interactions in Bone |
JUL 2003 |
29 pages |
| Authors:
Normand Pouliot; Robin L. Anderson; PETER MACCALLUM CANCER INST MELBOURNE (AUSTRALIA)
|
| We are investigating interactions between breast cancer and bone stromal cells and their role in regulating metastasis of breast tumor cells to bone and osteoclast development using an orthotopic mouse model. Results from in vivo experiments indicate that PTHrP is an important factor regulating tumor growth but is not required for specific metastasis of breast tumors to bone. In vitro co-culture of bone stromal and tumor cells leads to up-regulation ... |
|
| Breast Tumor/Stromal Cell Interactions in Bone |
JUL 2002 |
14 pages |
| Authors:
Michael D. Tavaria; Robin L. Anderson; PETER MACCALLUM CANCER INST MELBOURNE (AUSTRALIA)
|
| Metastasis to bone is a common and serious complication of breast cancer. The aim of this project is to use our unique mouse model of breast cancer metastasis to bone to identify the molecular basis for this problem. In the first year, we have investigated the expression of a panel of candidate genes in tumor cells that metastasize to bone compared to those that do not metastasize or that metastasize ... |
|
| Mechanisms of Bone Metastasis from Breast Cancer Using a Clinically Relevant Model |
JUL 2001 |
62 pages |
| Authors:
Robin L. Anderson; PETER MACCALLUM CANCER INST MELBOURNE (AUSTRALIA)
|
| Bone metastases develop in 70% of breast cancer patients who are left untreated or for whom treatment fails. Once the tumor has metastasised, the disease is hard to control and treatment options are limited. A lack of knowledge of the metastasis process and the genes that control it precludes the use of rational drug design. Breast cancer metastasis to bone is poorly understood largely due to a dearth of model ... |
|
| Mechanisms of Bone Metastasis from Breast Cancer Using a Clinically Relevant Model |
JUL 1999 |
23 pages |
| Authors:
Robin L. Anderson; PETER MACCALLUM CANCER INST MELBOURNE (AUSTRALIA)
|
| We have developed and characterised a model of breast cancer metastasis to bone that overcomes the deficiencies of earlier models. It utilises clones of a spontaneous mammary carcinoma that, after orthotopic injection of the tumor cells into the mammary gland, metastasise to bone and cause hypercalcemia. In addition, metastases are detected in some other organs, mainly lungs and liver. Other clones derived from the same primary tumor either do not ... |
|
Reports by Author
