Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The alpha emitting radioisotopes Tb-149 and Bi-213 were produced by accelerator and generator, respectively, and chelated to cancer affined monoclonal antibody, peptide or protein to form the alpha-immunoconjugates (AIC) and alpha-plasminogen activation inhibitor type-2 (API) against melanoma, leukaemia, breast, prostate and colorectal cancers. These conjugates are tested ...
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